An investigation of ER stress response on vascular remodeling and atherosclerosis

• Project/Area Number: 23791012
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: GAO Junhong 東北大学, 大学院・医学系研究科, 助教 (70455781)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 動脈硬化 / メタボリックシンドローム / 小胞体ストレス / 糖尿病

Research Abstract

Metabolism in different tissues/organs is regulated via both neuronal and humoral factors. We have previously demonstrated that neuronal networks, especially from the liver, play important roles in maintaining metabolic homeostasis among organs/tissues, including adipose tissue and pancreatic islets. Nutrient (carbohydrate, fat, and protein) overloads due to overeating affect these regulational systems, resulting in progression of metabolic disorders. In this study, we purpose to identify a new role of hepatic amino acid metabolism on the development of metabolic syndrome.

Research Products

• [Journal Article] Importance of endothelial NF-κB signaling in vascular remodeling and aortic aneurysm formation (2012)
  • Author(s): Saito T, Hasegawa Y, Ishigaki Y, Yamada T, Gao J, Imai J, Uno K, Kaneko K, Ogihara T, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H.
  • Journal Title: Cardiovascular Research Volume: 97(1) Issue: 1 Pages: 106-114
  • DOI: 10.1093/cvr/cvs298
  • Peer Reviewed
• [Journal Article] Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans (2012)
  • Author(s): Hasegawa Y, Fujita T, et al.
  • Journal Title: Circulation Volume: 125 Issue: 9 Pages: 1122-1133
  • DOI: 10.1161/circulationaha.111.054346
  • Peer Reviewed
• [Journal Article] Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vasal signals (2012)
  • Author(s): Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H
  • Journal Title: Eur Heart J Volume: (In Press) Issue: 10 Pages: 1279-1289
  • DOI: 10.1093/eurheartj/ehr265
  • Peer Reviewed
• [Journal Article] Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses (2011)
  • Author(s): Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H.
  • Journal Title: Circulation Volume: 124(7) Pages: 830-839
  • Peer Reviewed
• [Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses (2011)
  • Author(s): Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, HasegawaY, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H
  • Journal Title: Circulation Volume: 124 Issue: 7 Pages: 830-839
  • DOI: 10.1161/circulationaha.110.014050
  • Peer Reviewed
• [Presentation] Bach 1 dificiency protects pancreatic bepa cells from oxidative stress injury (2012)
  • Author(s): Kondo K, Ishigaki Y , Gao J, Yamada T, Imai J, Sawada S, Muto A, Oka Y, Igarashi K, Katagiri H.
  • Organizer: 48th European Association for theStudy of Diabetes Annual Meeting
  • Place of Presentation: Berlin,Germany
• [Presentation] BTB and CNC homology 1(Bach1)欠損による膵β細胞保護効果 (2012)
  • Author(s): 近藤敬一,石垣泰,高俊弘,澤田正二郎,山田哲也,今井淳太,鈴木亨,本間緑,武藤哲彦,五十嵐和彦,岡芳知,片桐秀樹
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
• [Presentation] Bach1 deficiency protects pancreatic beta cells from oxidative stress injury (2012)
  • Author(s): Keiichi Kondo, Y. Ishigaki, J. Gao, T. Yamada, J. Imai, S. Sawada, A. Muto, Y. Oka, K. Igarashi, H. Katagiri
  • Organizer: 48th EASD Annual Meeting
  • Place of Presentation: Germany,Berlin
  • Invited
• [Presentation] 動脈硬化発症・進展におけるWSF1の役割の検討 (2011)
  • Author(s): 高俊弘,石垣泰,澤田正二郎,近藤敬一,井泉知仁,宇野健司,長谷川豊,山口賢,金子慶三,突田壮平,高橋圭,今井淳太,山田哲也,石原寿光,岡芳知,片桐秀樹
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
• [Presentation] 動脈硬化発症・進展におけるWSF1の役割の検討
  • Author(s): 高 俊弘、石垣 泰、澤田正二郎、近藤 敬一、井泉 知仁、宇野 健司、長谷川 豊、山口 賢、金子 慶三、突田 壮平、高橋 圭、今井 淳太、山田 哲也、石原 寿光、岡 芳知、片桐 秀樹
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌