| Project/Area Number |
23791012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
GAO Junhong 東北大学, 大学院・医学系研究科, 助教 (70455781)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 動脈硬化 / メタボリックシンドローム / 小胞体ストレス / 糖尿病 |
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| Research Abstract |
Metabolism in different tissues/organs is regulated via both neuronal and humoral factors. We have previously demonstrated that neuronal networks, especially from the liver, play important roles in maintaining metabolic homeostasis among organs/tissues, including adipose tissue and pancreatic islets. Nutrient (carbohydrate, fat, and protein) overloads due to overeating affect these regulational systems, resulting in progression of metabolic disorders. In this study, we purpose to identify a new role of hepatic amino acid metabolism on the development of metabolic syndrome.
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