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Molecular biological analysis of GLP-1 releasing neurons in the brainstem

Research Project

Project/Area Number 23791035
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionSaga University

Principal Investigator

HISADOME Kazunari  佐賀大学, 医学部, 助教 (00592081)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords中枢神経 / 薬理学 / メタボリックシンドローム / GLP-1 / 糖尿病 / 内分泌 / 神経生理 / 代謝学 / 肥満
Research Abstract

GLP-1 releasing neurons show no response when gut peptides (such as GLP-1, Peptide YY and ghrelin) were applied, whereas GLP-1 releasing neurons were depolarized by leptin. CCK increased the frequency of glutamatergic synaptic inputs onto GLP-1 releasing neurons. The effects of CCK on GLP-1 releasing neurons were prevented by the pretreatment of yohimbine. Moreover, phenylephrine, a selective α1-receptor agonist, mimicked the effects of CCK on GLP-1 releasing neurons. Electrical stimulation of solitary tract showed that GLP-1 releasing neurons received direct synaptic input from vagal afferent fibers.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] CCK stimulation of GLP-1 neurons involves a_1-adrenoceptor-mediated increase in glutamatergic synaptic inputs2011

    • Author(s)
      Hisadome K, Reiman F, Gribble FM, Trapp S
    • Journal Title

      Diabetes

      Volume: 60 (11) Issue: 11 Pages: 2701-2709

    • DOI

      10.2337/db11-0489

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucagon-like peptide 1 and the brain: central actions -central sources?2011

    • Author(s)
      Trapp S, Hisadome K
    • Journal Title

      Autonomic Neuroscience

      Volume: 161(1-2) Issue: 1-2 Pages: 14-19

    • DOI

      10.1016/j.autneu.2010.09.008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.2011

    • Author(s)
      Hisadome Kazunari
    • Journal Title

      Diabetes

      Volume: 60 (11) Pages: 2701-2709

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Excitatory effects of CCK on GLP-1 releasing neurons are mediated via adrenergic neurons.2013

    • Author(s)
      久留 和成
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] GLP-1分泌神経細胞におけるグルコース受容ニューロンの解析2013

    • Author(s)
      久留 和成
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] GLP-1 分泌神経細胞のグルコース応答に関する解析2012

    • Author(s)
      久留 和成
    • Organizer
      第65回 日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Year and Date
      2012-11-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuromodulatory effects of feeding peptides in GLP-1 releasing neurons of mouse brainstem.2012

    • Author(s)
      久留 和成
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] GLP-1分泌神経細胞におけるアドレナリン作動性神経を介したCCK興奮作用2012

    • Author(s)
      久留 和成
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳幹GLP-1分泌細胞におけるアドレナリン受容体を介した興奮性シナプス入力の解析2011

    • Author(s)
      久留 和成
    • Organizer
      第64回 日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳幹GLP-1分泌細胞におけるアドレナリン受容体を介した興奮性シナプス入力の解析2011

    • Author(s)
      久留 和成
    • Organizer
      第64回 日本薬理学会西南部会
    • Place of Presentation
      KKRホテル博多(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] GLP-1分泌神経細胞の細胞外グルコース応答に関する解析

    • Author(s)
      久留 和成
    • Organizer
      第65回 日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
  • [Remarks] 所属研究室ホームページ

    • URL

      http://www.pharmacology.med.saga-u.ac.jp/YAKURIHP/Top_Page.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 佐賀大学 医学部 生体構造機能学 薬理学教室ホームページ

    • URL

      http://www.pharmacology.med.saga-u.ac.jp/YAKURIHP/Top_Page.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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