| Project/Area Number |
23791053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
SONE Masakatsu 京都大学, 医学研究科, 講師
TAURA Daisuke , 日本学術振興会特別研究員(PD)
HONDA Kyoko 京都大学, 医学研究科, 大学院生
KOJIMA Katsutoshi 京都大学, 医学研究科, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ヒト胚性幹細胞 / ヒト誘導多能性幹細胞 / 副腎 / ステロイドホルモン / 再生 / 再生医療 / ES細胞 / iPS細胞 / ステロイド / 副腎皮質 / 性腺 |
|---|
| Research Abstract |
The purpose of our present study was to establish a method for inducing differentiation of human ES/iPS cells into steroid-producing cells. We showed that human ES/iPS cells can be induced to differentiate into mesodermal lineage cells by Wnt signaling pathway activation and that subsequent introduction of SF-1 can induce the mesodermal lineage cells to differentiate into steroid-producing cells with the characteristics of adrenal cortical cells.
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