Differentiation of human embryonic stem cells and human induced pluripotent stem cells into steroid-producing cells.
| Project/Area Number |
23791053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
SONE Masakatsu 京都大学, 医学研究科, 講師
TAURA Daisuke , 日本学術振興会特別研究員(PD)
HONDA Kyoko 京都大学, 医学研究科, 大学院生
KOJIMA Katsutoshi 京都大学, 医学研究科, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ヒト胚性幹細胞 / ヒト誘導多能性幹細胞 / 副腎 / ステロイドホルモン / 再生 / 再生医療 / ES細胞 / iPS細胞 / ステロイド / 副腎皮質 / 性腺 |
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| Research Abstract |
The purpose of our present study was to establish a method for inducing differentiation of human ES/iPS cells into steroid-producing cells. We showed that human ES/iPS cells can be induced to differentiate into mesodermal lineage cells by Wnt signaling pathway activation and that subsequent introduction of SF-1 can induce the mesodermal lineage cells to differentiate into steroid-producing cells with the characteristics of adrenal cortical cells.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] A case of myelolipoma with bilateral adrenal hyperaldosteronism cured after unilateral adrenalectomy.2012
Author(s)
Inuzuka M, Tamura N, Sone M, Taura D,Sonoyama T, Honda K, Kojima K, Fukuda Y, Ueda Y, Yamashita Y, Kondo E, Yamada G, Fujii T, Miura M, Kanamoto N, Yasoda A, Arai H, Mikami Y, Sasano H, Nakao K.
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Journal Title
Intern Med.
Volume: 51
Pages: 479-85
NAID
URL
Related Report
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