Investigation of the novel biological role of neuromedin S

• Project/Area Number: 23791065
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: MORI Miwa 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (50363148)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 内分泌 / 神経ペプチド / 生理活性ペプチド / ニューロメジンS

Research Abstract

The regional distribution of neuromedin S (NMS) in the rat brain was investigated using a highly sensitive radioimmunoassay. A high content of NMS peptide was found in the hypothalamus, midbrain, and pons-medulla oblongata, whereas abundant expression of NMS mRNA was detected only in the hypothalamus. These differing distributions of the mRNA and peptide suggest that nerve fibers originating from hypothalamic NMS neurons project into the brainstem. These results suggest novel, unknown physiological roles of NMS within the brainstem.

Research Products

• [Journal Article] Different distribution of neuromedin S and its mRNA in the rat brain: NMS peptide is present not only in the hypothalamus as the mRNA, but also in the brainstem (2012)
  • Author(s): Mori M, Mori K, Ida T, Sato T, Kojima M, Miyazato M, Kangawa K
  • Journal Title: Front Endocrinol (Lausanne) Volume: 3 Pages: 152-152
  • DOI: 10.3389/fendo.2012.00152
  • Peer Reviewed
• [Journal Article] ニューロメジンＳとその多様な機能 (2011)
  • Author(s): 森健二、森美和、宮里幹也、寒川賢治
  • Journal Title: Comparative Endocrinology Volume: 37 Issue: 142 Pages: 124-133
  • DOI: 10.5983/nl2008jsce.37.124
  • NAID: 130004509341
  • ISSN: 1882-6636, 1882-6644
• [Presentation] ニューロメジンS の機能と脳内分布 (2012)
  • Author(s): 森美和、森健二、宮里幹也、寒川賢治
  • Organizer: 第9回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-11
• [Presentation] ニューロメジンS の機能と脳内分布 (2012)
  • Author(s): 森健二、森美和、宮里幹也、寒川賢治
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-04-21
• [Presentation] Function and regional distribution of neuromedin S in rat brain (2011)
  • Author(s): 森美和、森健二、宮里幹也、寒川賢治
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Function and regional distribution of neuromedin S in rat brain (2011)
  • Author(s): 森美和、森健二、宮里幹也、寒川賢治
  • Organizer: 日本生化学会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] ニューロメジンSの機能と脳内分布
  • Author(s): 森美和，森健二，宮里幹也，寒川賢治
  • Organizer: 第9回GPCR研究会
  • Place of Presentation: 東京
• [Presentation] ニューロメジンSの機能と脳内分布
  • Author(s): 森健二，森美和，宮里幹也，寒川賢治
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 愛知・名古屋