The role of histone demethylase in chromosomal translocations : The dynamic modification of chromosomal structure

• Project/Area Number: 23791089
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Jichi Medical University
• Principal Investigator: WADA Taeko 自治医科大学, 医学部, 助教 (30382956)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 造血器腫瘍 / ヒストン脱メチル化酵素 / 染色体異常

Research Abstract

We found that the expression of histone demethylase LSD1 is very low in normal human hematopoietic stem/progenitor cells (HSPC) and considerably higher in AML cells. We identified that only two isoforms were expressed in hematopoietic cells

Research Products

• [Journal Article] Homopiperazine Derivatives as a Novel Class of Proteasome Inhibitors with a Unique Mode of Proteasome Binding. (2013)
  • Author(s): Kikuchi J.
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e60649-e60649
  • DOI: 10.1371/journal.pone.0060649
  • Peer Reviewed
• [Journal Article] Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8 (2012)
  • Author(s): Wada T, Kikuchi J, Furukawa Y
  • Journal Title: EMBO Reports Volume: 13 Issue: 2 Pages: 142-149
  • DOI: 10.1038/embor.2011.247
  • Peer Reviewed
• [Journal Article] Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells (2012)
  • Author(s): Mitsunaga K, Kikuchi J, Wada T, Furukawa Y
  • Journal Title: Journal of Cellular Physiology Volume: 227 Issue: 3 Pages: 1138-1147
  • DOI: 10.1002/jcp.22834
  • Peer Reviewed
• [Journal Article] Mechanisms of action and clinical effectiveness of the newly approved anti-cancer drug bendamustine (2011)
  • Author(s): Furukawa Y ., Hiraoka N., Wada T., Kikuchi J., Kano Y.
  • Journal Title: Nihon Yakurigaku Zasshi Volume: 138(1) Pages: 26-32
  • NAID: 10029417927
  • URL: https://www.jstage.jst.go.jp/article/fpj/138/1/138_1_26/_article
  • Peer Reviewed
• [Presentation] Aberrant Expression of Histone Demethylase LSD1/KDM1A in Acute Leukemia Cells (2012)
  • Author(s): 和田 妙子
  • Organizer: 日本血液学会
  • Place of Presentation: 国立京都国際会館
• [Presentation]
  • Organizer: 日本血液学会
• [Presentation]
  • Organizer: XXV IACRLRD
• [Remarks]
  • URL: http://www.jichi.ac.jp/stem/index.html
• [Remarks]
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=hwx2x4uhbivib6zkha3rgm6fbaxrfg&resultCd=1&sectionCd=121