The role of histone demethylase in chromosomal translocations : The dynamic modification of chromosomal structure
| Project/Area Number |
23791089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
WADA Taeko 自治医科大学, 医学部, 助教 (30382956)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 造血器腫瘍 / ヒストン脱メチル化酵素 / 染色体異常 |
|---|
| Research Abstract |
We found that the expression of histone demethylase LSD1 is very low in normal human hematopoietic stem/progenitor cells (HSPC) and considerably higher in AML cells. We identified that only two isoforms were expressed in hematopoietic cells
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Report
(3 results)
Research Products
(9 results)
