Investigation of the mechanisms regulating wheat allergen absorption through tight junction in the intestinal epithelial cells
| Project/Area Number |
23791114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Shimane University |
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Principal Investigator |
CHINUKI Yuko 島根大学, 医学部, 助教 (00294380)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アレルギー学 / 食物アレルギー / 抗原吸収 / 経消化管感作 / 経皮感作 / 小麦依存性運動誘発アナフィラキシー / 加水分解小麦 / 食物依存性運動誘発アナフィラキシー / 小麦 / 血中グリアジン濃度 / プロスタグランジン / 腸管上皮 / 粘膜バリアシステム |
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| Research Abstract |
In the past, food allergy was considered to be caused by sensitization to food allergens through oral intake. Recently, a new subtype of wheat-dependent exercise-induced anaphylaxis (WDEIA) caused by hydrolyzed wheat protein (HWP) has been observed. The patients with this new subtype were likely to be sensitized to HWP primarily through percutaneous and/or rhino-conjunctival routes by using a facial soap containing the HWP. According to our analysis, HWPs composed of large polypeptide aggregates possibly have higher allergenicity than lower-molecular-weight HWPs.
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Report
(3 results)
Research Products
(70 results)
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[Presentation] 加水分解コムギにより生じた WDEIA における負荷検査の結果と有用性2012
Author(s)
杉山晃子,岸川禮子,西江温子,下田照文,岩永知秋,西間三馨,嶋田清隆,古江増隆,田辺創一,千貫祐子,他
Organizer
第62回日本アレルギー学会秋季学術大会
Place of Presentation
大阪国際会議場(大阪市)
Related Report
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[Presentation] 加水分解小麦入り石鹸による感作が推測される,ω-5グリアジン特異 IgE 陽性の小麦依存性FDEIA3 例2012
Author(s)
足立厚子,西岡美南,福田佳奈子,一角直行,佐々木祥人,下浦真人,井口佳代,上田正登,千貫祐子,他
Organizer
第111回日本皮膚科学会総会
Place of Presentation
国立京都国際会館(京都市)
Related Report
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