Anti-G-CSF autoantibodies regulate neutrophil function in patiernt with bacterial pneumonia
| Project/Area Number |
23791119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Research Collaborator |
UCHIDA Kanji
NAKAGAKI Kazuhide
NAKATA Koh
GOTO Hajime
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 自己抗体 / G-CSF / 免疫複合体 / 細菌性肺炎 / IVIG / 健常者 / 市中肺炎 / キャリアプロテイン / 抗G-CSF自己抗体 / 肺炎 / 好中球 |
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| Outline of Final Research Achievements |
We developed a novel method to measure serum levels of anti-G-CSF autoantibody (G-CSF autoantibody) which conventional method failed to quantify. Both healthy individuals and patients with bacterial pneumonia had G-CSF autoantibodies in their sera. Serum G-CSF autoantibody levels positively correlated with white blood cell counts, neutrophil counts, and C-reactive protein levels. G-CSF autoantibodies did not neutralize G-CSF bioactivity (non-neutralizing antibody). G-CSF-autoantibody immune complex were present in sera of pneumonia patients. Thus, G-CSF autoantibodies works as carrier protein for G-CSF.
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Report
(5 results)
Research Products
(2 results)
