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Development of analysis tools for epidermal gdT cells, and its functional analysis

Research Project

Project/Area Number 23791123
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionJuntendo University

Principal Investigator

SHIMURA ERI  順天堂大学, 医学(系)研究科(研究院), 研究員 (30586342)

Research Collaborator NAKAE Susumu  東京大学, 医科学研究所, 准教授 (60450409)
SUDO Katsuko  東京医科大学, 医学部, 講師 (50126091)
SUTO Hajime  順天堂大学, 医学部, 准教授 (90286740)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords表皮gdT細胞 / 皮膚免疫 / 接触性皮膚炎 / gdT細胞 / アレルギー / 表皮γδT細胞 / 皮膚免疫応答
Research Abstract

Previous studies suggested that DETCs (dendritic epidermal T cells) which present in the epidermis of mouse skin plays an important role in skin diseases such as wound healing, skin cancer and contact hypersensitivity. However, the precise role of DETCs in these skin diseases is poorly understood.
We searched for candidate genes that expressed DETCs-specific manner, aiming to establish of an analysis tool that is specialized in the detection of DETCs and to elucidate the function of DETCs. On the other hand, we attempted to elucidate the function of DETCs in contact hypersensitivity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Book (3 results)

  • [Journal Article] Th17 cel1-derived IL-17 is dispensable for B cell antibody production.2012

    • Author(s)
      Akiko Shibui
    • Journal Title

      Cytokine

      Volume: 1 Issue: 1 Pages: 108-114

    • DOI

      10.1016/j.cyto.2012.03.018

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma2012

    • Author(s)
      Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S
    • Journal Title

      Journal of Immunology

      Volume: 189(7) Pages: 3642-52

    • URL

      http://www.jimmunol.org/content/189/7/3641.long

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012

    • Author(s)
      Suzukawa M, Morita H, Nambu A, Arae K,Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H,Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH,Matsumoto K, Nakae S.
    • Journal Title

      J immunol.

      Volume: 189(7) Issue: 7 Pages: 3641-52

    • DOI

      10.4049/jimmunol.1200461

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of IL-17 in Contact Dermatitis2012

    • Author(s)
      Eri SHIMURA, Susumu Nakae
    • Journal Title

      J Environ Dermatol Cutan Allergol

      Volume: 6(5) Pages: 417-426

    • NAID

      10031126925

    • Related Report
      2012 Research-status Report
  • [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion2011

    • Author(s)
      S.Itoh
    • Journal Title

      Circulation

      Volume: 124 Issue: 11_suppl_1

    • DOI

      10.1161/circulationaha.110.014852

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alteration of Immune Responses by N-acetylglucosaminyltransferase V during Allergic Airway Inflammation2011

    • Author(s)
      Akiko Shibui
    • Journal Title

      Allergology International

      Volume: 60 Issue: 3 Pages: 345-354

    • DOI

      10.2332/allergolint.10-OA-0283

    • NAID

      130004723047

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Regulation of contact hypersensitivity by interleukin-212013

    • Author(s)
      SHIMURA Eri
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2013-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of contact hypersensitivity by Interleukin-212013

    • Author(s)
      SHIMURA Eri
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Further screeing of novel house dust mite DNA vaccine candidates reveals new effective clones2013

    • Author(s)
      SHIBUI Akiko
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulatory roles of IL-21 receptor in contact hypersensitivity2012

    • Author(s)
      SHIMURA Eri
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場、神戸ポートピアホテル
    • Year and Date
      2012-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory roles of IL-21 receptor in contact hypersensitivity2012

    • Author(s)
      SHIMURA Eri, SHIBUI Akiko, NAKANISHI Wakako, NAMBU Aya, OKUMURA Ko, NAKAE Susumu
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場 神戸ポートピアホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] The role of IL-21 receptor in contact hypersensitivity2011

    • Author(s)
      SHIMURA Eri
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of IL-21 receptor in contact hypersensitivity2011

    • Author(s)
      Shimura Eri
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2011 Research-status Report
  • [Book] Role of IL-17 in contact hypersensitivity, J Environ Dermatol Cutan Allergol2012

    • Author(s)
      Eri SHIMURA, Susumu Nakae
    • Related Report
      2013 Final Research Report
  • [Book] アレルギーの臨床2011

    • Author(s)
      志村絵理・中江進
    • Publisher
      北隆館
    • Related Report
      2013 Final Research Report
  • [Book] アレルギーの臨床2011

    • Author(s)
      志村 絵理・中江 進
    • Total Pages
      92
    • Publisher
      北隆館
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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