The effect of macrolide antibiotics on co-infection of influenza virus and Strepto-coccus pneumoniae in mice.

• Project/Area Number: 23791139
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: MORITA Towako 長崎大学, 医歯(薬)学総合研究科, 客員研究員 (50569960)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 感染症防御学 / インフルエンザウイルス / macrolide / influenza / clarithromycin / PAF receptor / 肺炎球菌 / 重複感染 / マクロライド系抗菌薬 / サイトカイン / PAFレセプター

Research Abstract

Secondary bacterial pneumonia is one of the complications in patients with influenza virus infection. Macrolide antibiotics (MCLs) are known to have immunomodulatory effects beyond antibacterial activity and recently reported to have direct effect on influenza epidemic. Based on these backgrounds, the aim of our study was to determine the inhibitory effect of macrolide antibiotics on coinfection of influenza virus and S. pneu-moniae in mice. We conclude that CAM improved survival time of influenza virus and S. pneumoniae coinfection mice model and that CAM could play a beneficial role in influenza virus and S. pneumoniae coinfection by inducing Th1 cytokines and suppressing PAF receptor expression.

Research Products

• [Presentation] The effect of macrolide antibiotics on co-infection of influenza virus and Streptococcus pneumoniae in mice (2013)
  • Author(s): Tatsuhiko Harada, Towako Morita, Yuji Ishimatsu, et al
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Pennsylvania convention center (Philadelphia, America)
  • Year and Date: 2013-05-22
• [Presentation] The effect of macrolide antibiotics on co-infection of influenza virus and Streptococcus pneumoniae in mice. (2013)
  • Author(s): Tatsuhiko Harada, Towako Morita, Yuji Ishimatsu
  • Organizer: American Thoracic Society International Conference.
  • Place of Presentation: Pennsylvania convention center (Philadelphia, America）
• [Presentation] インフルエンザウイルスおよび肺炎球菌の重複感染マウスにおけるマクロライド系抗菌薬の効果 (2013)
  • Author(s): 中島章太
  • Organizer: 第12回肺分子病態研究会
  • Place of Presentation: ホテルレオパレス博多
• [Presentation] インフルエンザウイルスおよび肺炎球菌の重複感染マウスにおけるマクロライド系抗菌薬の効果 (2013)
  • Author(s): 原田達彦
  • Organizer: 第14回長崎マクロライド研究会
  • Place of Presentation: ホテルニュー長崎
• [Presentation] The effect of macrolide antibiotics to severe pneumonia due to influenza virus and Streptcoccus pneumoniae coinfection in mice. (2013)
  • Author(s): 原田達彦
  • Organizer: American Thoracic Society International Conference 2013
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia