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The effect of macrolide antibiotics on co-infection of influenza virus and Strepto-coccus pneumoniae in mice.

Research Project

Project/Area Number 23791139
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionNagasaki University

Principal Investigator

MORITA Towako  長崎大学, 医歯(薬)学総合研究科, 客員研究員 (50569960)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords感染症防御学 / インフルエンザウイルス / macrolide / influenza / clarithromycin / PAF receptor / 肺炎球菌 / 重複感染 / マクロライド系抗菌薬 / サイトカイン / PAFレセプター
Research Abstract

Secondary bacterial pneumonia is one of the complications in patients with influenza virus infection. Macrolide antibiotics (MCLs) are known to have immunomodulatory effects beyond antibacterial activity and recently reported to have direct effect on influenza epidemic. Based on these backgrounds, the aim of our study was to determine the inhibitory effect of macrolide antibiotics on coinfection of influenza virus and S. pneu-moniae in mice. We conclude that CAM improved survival time of influenza virus and S. pneumoniae coinfection mice model and that CAM could play a beneficial role in influenza virus and S. pneumoniae coinfection by inducing Th1 cytokines and suppressing PAF receptor expression.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013

All Presentation (5 results)

  • [Presentation] The effect of macrolide antibiotics on co-infection of influenza virus and Streptococcus pneumoniae in mice2013

    • Author(s)
      Tatsuhiko Harada, Towako Morita, Yuji Ishimatsu, et al
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Pennsylvania convention center (Philadelphia, America)
    • Year and Date
      2013-05-22
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of macrolide antibiotics on co-infection of influenza virus and Streptococcus pneumoniae in mice.2013

    • Author(s)
      Tatsuhiko Harada, Towako Morita, Yuji Ishimatsu
    • Organizer
      American Thoracic Society International Conference.
    • Place of Presentation
      Pennsylvania convention center (Philadelphia, America)
    • Related Report
      2013 Annual Research Report
  • [Presentation] インフルエンザウイルスおよび肺炎球菌の重複感染マウスにおけるマクロライド系抗菌薬の効果2013

    • Author(s)
      中島章太
    • Organizer
      第12回肺分子病態研究会
    • Place of Presentation
      ホテルレオパレス博多
    • Related Report
      2012 Research-status Report
  • [Presentation] インフルエンザウイルスおよび肺炎球菌の重複感染マウスにおけるマクロライド系抗菌薬の効果2013

    • Author(s)
      原田達彦
    • Organizer
      第14回長崎マクロライド研究会
    • Place of Presentation
      ホテルニュー長崎
    • Related Report
      2012 Research-status Report
  • [Presentation] The effect of macrolide antibiotics to severe pneumonia due to influenza virus and Streptcoccus pneumoniae coinfection in mice.2013

    • Author(s)
      原田達彦
    • Organizer
      American Thoracic Society International Conference 2013
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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