Research Project
Grant-in-Aid for Young Scientists (B)
Secondary bacterial pneumonia is one of the complications in patients with influenza virus infection. Macrolide antibiotics (MCLs) are known to have immunomodulatory effects beyond antibacterial activity and recently reported to have direct effect on influenza epidemic. Based on these backgrounds, the aim of our study was to determine the inhibitory effect of macrolide antibiotics on coinfection of influenza virus and S. pneu-moniae in mice. We conclude that CAM improved survival time of influenza virus and S. pneumoniae coinfection mice model and that CAM could play a beneficial role in influenza virus and S. pneumoniae coinfection by inducing Th1 cytokines and suppressing PAF receptor expression.
All 2013
All Presentation (5 results)