Evaluation between gene-polymorphism and efficacy of therapy for pulmonary arterial hypertension using next-generation DNA analysis system

• Project/Area Number: 23791144
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Asahikawa Medical College
• Principal Investigator: SUGIMOTO Masaya 旭川医科大学, 医学部, 助教 (20400096)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肺高血圧症 / 先天性心疾患 / 肺高血圧

Research Abstract

We studied pulmonary arterial hypertension in children with congenital heart disease. Serum high sensitivity cTnI levels significantly correlated with Pp/Ps in children. The Qs and Qp/Qs obtained by MRI strongly correlated with those obtained by catheterization, and a significant correlation was observed between the MCFR and Pp/Ps. Moreover, unlike patients with regressed CALs (coronary arterial lesion) in Kawasaki Disease, patients with persistent CALs have abnormal mechanical properties and hemodynamics of the pulmonary artery.

Research Products

• [Journal Article] オーバーラップする疾患群:ミトコンドリア病と左室心筋緻密化障害 (2014)
  • Author(s): 杉本昌也,桑田聖子,先崎秀明
  • Journal Title: 小児循環器学会雑誌 Volume: 30巻2号 Pages: 130-132
  • NAID: 130003398260
• [Journal Article] オーバーラップする疾患群：ミトコンドリア病と左室心筋緻密化障害 (2014)
  • Author(s): 杉本昌也, 桑田聖子, 先崎秀明
  • Journal Title: 日本小児循環器学会雑誌 Volume: 30 Pages: 130-132
  • NAID: 130003398260
• [Journal Article] Assessment of pulmonary arterial pressure by velocity-encoded cine magnetic resonance imaging in children with congenital heart disease (2013)
  • Author(s): Sugimoto M, Kajino H, Azuma H
  • Journal Title: Circ Journal Volume: 77(12) Pages: 3015-3022
  • NAID: 10031203588
  • Peer Reviewed
• [Journal Article] Pulmonary Arterial Wall Stiffness and Its Impact on Right Ventricular Afterload in Patients With Repaired Tetralogy of Fallot (2013)
  • Author(s): Inuzuka R, Sugimoto M, Senzaki H
  • Journal Title: Ann Thorac Surg Volume: 96 Pages: 1435-1441
  • Peer Reviewed
• [Journal Article] Assessment of Pulmonary Arterial Pressure by Velocity-Encoded Cine Magnetic Resonance Imaging in Children With Congenital Heart Disease (2013)
  • Author(s): 1. Sugimoto M, Kajino H, Kajihama A, Nakau K, Murakami N, Azuma H
  • Journal Title: Circulation Journal Volume: 77 Issue: 12 Pages: 3015-3022
  • DOI: 10.1253/circj.CJ-13-0626
  • NAID: 10031203588
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Pulmonary Arterial Wall Stiffness and Its Impact on Right Ventricular Afterload in Patients With Repaired Tetralogy of Fallot. (2013)
  • Author(s): Ryo Inuzuka, Mitsuru Seki, Masaya Sugimoto, Hirofumi Saiki, Satoshi Masutani, Hideaki Senzaki
  • Journal Title: Ann Thorac Surg Volume: 96 Issue: 4 Pages: 1435-1441
  • DOI: 10.1016/j.athoracsur.2013.05.085
  • Peer Reviewed
• [Journal Article] Findings in the pulmonary vascular bed in the remote phase after Kawasaki disease (2012)
  • Author(s): Sugimoto M, lshido H, Senzaki H
  • Journal Title: Am J Cardiol Volume: 109(8) Pages: 1219-22
  • Peer Reviewed
• [Journal Article] Findings in the pulmonary vascular bed in the remote phase after Kawasaki disease. (2012)
  • Author(s): Sugimoto M, Ishido H, Seki M, Masutani S, Tamai A, Senzaki H.
  • Journal Title: Am J Cardiol Volume: 109 (8) Issue: 8 Pages: 1219-1222
  • DOI: 10.1016/j.amjcard.2011.11.062
  • Peer Reviewed
• [Journal Article] Volume overload and pressure overload due to left-to right shunt induced myocardial injury: evaluation using a highly sensitive cardiac troponin-I assay in children with congenital heart disease (2011)
  • Author(s): Sugimoto M, Ota K, Kajino H
  • Journal Title: Circulation Journal Volume: 75(9) Pages: 2213-2219
  • NAID: 10029339810
  • Peer Reviewed
• [Presentation] Constantly changing biological reactions and biomarkers during exercise in Fontan circulation (2014)
  • Author(s): Sugimoto M, Azuma H
  • Organizer: ESC congress 2014
  • Place of Presentation: Barcelona, Spain.(発表予定)
• [Presentation] Constantly changing biological reactions and biomarkers during exercise in Fontan circulation (2014)
  • Author(s): Sugimoto Masaya
  • Organizer: ESC congress 2014
  • Place of Presentation: Barcellona
• [Presentation] フォンタン循環における運動時の刻々と変化する生体反応とバイオマーカー (2013)
  • Author(s): 杉本昌也, 東寛
  • Organizer: 第33回日本小児循環動態研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-10-27
• [Presentation] 先天性心疾患患者における肺高血圧の評価に血中高感度心筋トロポニンI とT はどちらが優れているか (2013)
  • Author(s): 杉本昌也, 梶野浩樹, 東寛
  • Organizer: 第49回日本小児循環器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-07-10
• [Presentation] Noninvasive evaluation of the pulmonary arterial pressure using velocity-encoded cine MRI in children with congenital heart disease (2013)
  • Author(s): 杉本昌也,梶野浩樹,東寛
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-16
• [Presentation] Soluble fms-like tyrosine kinase 1 and placental growth factor ratio - a novel biomarker for assessing congestion and angiogenesis in children with congenital heart disease (2013)
  • Author(s): Sugimoto M, Azuma H
  • Organizer: AHA scientific sessions 2013
  • Place of Presentation: Dallas, USA
• [Presentation] Soluble fms-like tyrosine kinase 1 and placental growth factor ratio – a novel biomarker for assessing congestion and angiogenesis in children with congenital heart disease． (2013)
  • Author(s): Sugimoto Masaya
  • Organizer: AHA scientific sessions 2013
  • Place of Presentation: Ｄａｌｌａｓ
• [Presentation] 肺循環評価におけるVelocity-encoded cine MRI の優位性 (2012)
  • Author(s): 杉本昌也, 梶野浩樹
  • Organizer: 第48回日本小児循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-07-05
• [Presentation] Assessment of pulmonary arterial pressure in children with congenital heart disease by velocity-encoded cine magnetic resonance imaging (2012)
  • Author(s): Sugimoto M, Azuma H
  • Organizer: AHA scientific sessions 2012
  • Place of Presentation: Los Angeles, USA
• [Presentation] Assessment of pulmonary arterial pressure in children with congenital heart disease by velocity-encoded cine magnetic resonance imaging (2012)
  • Author(s): 杉本昌也
  • Organizer: AHA scientific sessions 2012
  • Place of Presentation: Los Angeles
• [Book] Hemodynamics: Monitoring, Theory and Applications - Serological Monitoring of Hemodynamics (2013)
  • Author(s): Sugimoto M, Senzaki H
  • Publisher: Nova Sciences Publishers
• [Book] HeartView, 16(12)増刊号 (2012)
  • Author(s): 杉本昌也
  • Publisher: メジカルビュー社
• [Book] 小児内科・43 増刊号 (2012)
  • Author(s): 杉本昌也,梶野浩樹
  • Publisher: 東京医学社