Epigenetic regulation and anti-tumor mechanisms of STAT3 in tumor bearing mouse model
Project/Area Number |
23791150
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
|
Research Institution | Yamagata University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 抗腫瘍免疫 / 樹状細胞療法 / STAT3 / エピジェネティックス / HDAC / エピジェネティクス |
Research Abstract |
Epigenetic regulation via STAT3 and HDACs in bone marrow derived dendritic cells potentially enhances anti-tumor effect. In this study, we demonstrated the STAT3-HDAC7 axis had a key role and induces tumor elimination in tumor bearing mouse model. The STAT3 deficient dendritic cells revealed enhanced expression of MHC class II, CD80, 86, 40 and IL-12, IL-6, IL-10 expression. In this model, STAT3 bound HDAC7 promoter and probably regulates cytokine expression. Thus, HDACs uniquely regulate tumor growth with STAT3. And the therapeutic application of HDACi should be elucidated in the future.
|
Report
(4 results)
Research Products
(22 results)
-
-
-
-
-
-
-
[Presentation] 重症先天性好中球減少症の経過中, 5歳時急性脳症を契機に退行を認め神経発達障害が顕在化したHAX1を変異を有する女児2013
Author(s)
目黒亨,中村和幸,佐藤裕子,簡野美弥子,小野田正志,高橋憲幸,川上貴子,三井哲夫,加藤光広,早坂清
Organizer
第55回日本小児血液・がん学会
Place of Presentation
ヒルトン福岡シーホーク.福岡
Year and Date
2013-12-01
Related Report
-
-
-
[Presentation] 難治性免疫性血小板減少症6例の検討2013
Author(s)
簡野美弥子,小野田正志,目黒亨,高橋憲幸,佐藤裕子,川上貴子,仙道大,三井哲夫,早坂清
Organizer
第94回日本小児科学会山形地方会
Place of Presentation
山形医学交流会館.山形
Year and Date
2013-05-12
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Fetal Lung Interstitial Tumorと診断した新生児肺腫瘍の男児例2011
Author(s)
小野田正志,太田寛,簡野美弥子,川上貴子,高橋憲幸,早川裕子,加藤哲子,江村隆起,三井哲夫,大泉弘幸,早坂清
Organizer
第33回東北小児がん研究会
Place of Presentation
ホテルJALシティ仙台.仙台
Year and Date
2011-04-05
Related Report