Aberrant expression of LMO2 in B-precursor AL
Project/Area Number |
23791160
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
|
Research Institution | University of Yamanashi |
Principal Investigator |
HIROSE Kinuko 山梨大学, 医学工学総合研究部, 医学研究員 (70436880)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | LMO2 / B 細胞性白血病 / B細胞性白血病 |
Research Abstract |
In MLL-rearranged ALL cell lines,LMO2 protein expression wasrelatively low despite their higher gene expression levels of hHEX and LMO2. Andintroduction of siRNA against LMO2 into LMO2/ hHEX -expressing B-precursor ALL cell linessignificantly downregulated hHEX gene expression. These observations suggest theinvolvement of LMO2/hHEX pathway in leukemogenesis of B-precursor ALL particularly witht(17;19),but not MLL-arrangement.
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Report
(3 results)
Research Products
(4 results)