Aberrant expression of LMO2 in B-precursor AL

Research Project

Project/Area Number	23791160
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	University of Yamanashi
Principal Investigator	HIROSE Kinuko 山梨大学, 医学工学総合研究部, 医学研究員 (70436880)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	LMO2 / B 細胞性白血病 / B細胞性白血病
Research Abstract	In MLL-rearranged ALL cell lines,LMO2 protein expression wasrelatively low despite their higher gene expression levels of hHEX and LMO2. Andintroduction of siRNA against LMO2 into LMO2/ hHEX -expressing B-precursor ALL cell linessignificantly downregulated hHEX gene expression. These observations suggest theinvolvement of LMO2/hHEX pathway in leukemogenesis of B-precursor ALL particularly witht(17;19),but not MLL-arrangement.