Construction of validation system for regenerative therapy by glycan profiling technology
Project/Area Number |
23791210
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | National Research Institute for Child Health and Development |
Principal Investigator |
INOUE Mayu 独立行政法人国立成育医療研究センター, 細胞医療研究部, 研究員 (40596920)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 再生医療 / 幹細胞 / レクチン / 糖鎖プロファイリング / 間葉系幹細胞 / 多能性幹細胞 / 体性幹細胞 / 品質評価 / 糖鎖 / 細胞プロファイリング / 細胞品質管理 / 間葉系細胞 / 増殖能 / 分化能 / 糖鎖融解 |
Outline of Final Research Achievements |
The cell surface is covered with various glycoproteins, which play a crucial role in biological function. In this study, I aimed to define the status of somatic stem cells and pluripotent stem cells using glycan profiles. The glycan profiles promises to be of great value of stem cell validation for regenerative therapy, complementing more established methods such as gene expression analysis and epigenetic analysis.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability.2014
Author(s)
Fukawatase Y, Toyoda M, Okamura K, Nakamura K, Nakabayashi K, Takada S, Yamazaki-Inoue M, Masuda A, Nasu M, Hata K, Hanaoka K, Higuchi A, Takubo K, Umezawa A.
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Journal Title
Sci Rep
Volume: 4
Pages: 5421
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Monitoring of the damage to freeze-thawed cells by glycan profiling using a lectin microarray.2012
Author(s)
Kami D, Toyoda M, Yamazaki-Inoue M, Itakura Y, Watakabe K, Sakurai T, Takehara N, Ogata T, Matsubara H, Umezawa A, and Gojo S
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
Yokohama
Year and Date
20120613-20120616
Related Report
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