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Involvement of the type III sodium phosphate cotransporter Pit-1 in phosphate reabsorption

Research Project

Project/Area Number 23791216
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionResearch Institute, Osaka Medical Center for Maternal and Child Health

Principal Investigator

YAMAZAKI Miwa  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 研究員 (50455549)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsPit-1 / リン / りん / くる病
Outline of Final Research Achievements

Type III sodium phosphate cotransporter, Pit-1, is ubiquitously expressed in mammalian tissues and plays a role as intracellular phosphate transporter, although the function of Pit-1 remains unclear. We have reported that extracellular phosphate and FGF23, a phosphaturic hormone, trigger the signal transduction via Pit-1 and FGF receptor and the signaling shares the same downstream cascade and interacts. In the current study, we have isolated the cells of osteoblasts and osteocytes lineage from Hyp mice, a murine model for X-linked hypophosphatemia, and wild type mice, and obtained the Fgf23 and Pit-1 expression profiles. Increased Pit-1 expression in osteoblasts and osteocytes from adult Hyp mice may be a compensatory mechanism to adapt to the decrease in extracellular Pi levels after birth.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results,  Open Access: 2 results) Presentation (8 results) Remarks (6 results)

  • [Journal Article] Interleukin-1-induced acute bone resorption facilitates the secretion of fibroblast growth factor 23 into the circulation.2014

    • Author(s)
      Yamazaki M, Kawai M, Miyagawa K, Ohata Y, Tachikawa K, Kinoshita S, Nishino J, Ozono K, Michigami T.
    • Journal Title

      J Bone Miner Metab.

      Volume: 0 Issue: 3 Pages: 0-0

    • DOI

      10.1007/s00774-014-0598-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.2014

    • Author(s)
      Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: 0-0

    • DOI

      10.1371/journal.pone.0093840

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of hyp mice2014

    • Author(s)
      Okano T(12), 他13人
    • Journal Title

      J Bone Miner Res

      Volume: 印刷中 Issue: 7 Pages: 0-0

    • DOI

      10.1002/jbmr.2186

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development.2013

    • Author(s)
      Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T
    • Journal Title

      Hepatol Res

      Volume: 43 Issue: 11 Pages: 1211-1223

    • DOI

      10.1111/hepr.12069

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo.2013

    • Author(s)
      Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 4 Pages: 2414-2427

    • DOI

      10.1074/jbc.m112.410043

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] X連鎖性低リン血症性くる病マウスモデルHypの骨細胞においてはFGF/FGFRシグナルが活性化している2014

    • Author(s)
      道上敏美,宮川和晃,西野仁,山﨑美和,川井正信,大幡泰久,立川加奈子,高垣裕子,古郷幹彦,大薗惠一
    • Organizer
      第48回日本小児内分泌学会学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activation of FGF/FGF receptor signaling in the primary osteocytes isolated from hypophosphatemic Hyp mice2014

    • Author(s)
      Miyagawa K, Yamazaki M, Kawai M, Koshimizu T, Nshino J, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T
    • Organizer
      The 36th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Houston, USA
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Extracellular inorganic phosphate functions as a potent inducer of the Dmp1 expression2014

    • Author(s)
      Nishino J, Miyagawa K, Yamazaki M, Kawai M, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T
    • Organizer
      The 36th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Houston, USA
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activation of FGF/FGF receptor signaling in Hyp osteocytes2014

    • Author(s)
      Nishino J, Miyagawa K, Yamazaki M, Kawai M, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T
    • Organizer
      The 24th Annual Meeting of the Australian and New Zealand Bone and Mineral Society
    • Place of Presentation
      Queenstown, New Zealand
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hypマウス骨細胞におけるFGF/FGF receptorシグナルの活性化2014

    • Author(s)
      西野仁,宮川和晃,山﨑美和,川井正信,大幡泰久,立川加奈子,高垣裕子,古郷幹彦,大薗惠一,道上敏美
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞外無機リン酸はDmp1の発現を誘導し骨細胞分化を促進する2014

    • Author(s)
      西野仁,宮川和晃,川井正信,山﨑美和,立川加奈子,高垣裕子,古郷幹彦,大薗惠一,道上敏美
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] FGF23の血中分泌過程における破骨細胞性骨吸収の関与の可能性2012

    • Author(s)
      山崎美和
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Osteoclastic Bone Resorption might be Involved in the Secretion of FGF23 into Circulation2012

    • Author(s)
      山崎美和
    • Organizer
      The 34th annual meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, U.S.A.
    • Related Report
      2012 Research-status Report
  • [Remarks] 研究内容、環境影響部門、大阪府立母子保健総合医療センター研究所

    • URL

      http://www.mch.pref.osaka.jp/research/bone/content.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 業績、環境影響部門、大阪府立母子保健総合医療センター研究所

    • URL

      http://www.mch.pref.osaka.jp/research/bone/work.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究内容、環境影響部門、大阪府立母子保健総合医療センター研究所

    • URL

      http://www.mch.pref.osaka.jp/research/bone/content.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 業績、環境影響部門、大阪府立母子保健総合医療センター研究所

    • URL

      http://www.mch.pref.osaka.jp/research/bone/work.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 研究内容、環境影響部門、大阪府立母子保健総合医療センター研究所

    • URL

      http://www.mch.pref.osaka.jp/laboratory/environment/content.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 業績、環境影響部門、大阪府立母子保健総合医療センター研究所

    • URL

      http://www.mch.pref.osaka.jp/laboratory/environment/work.html

    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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