Analysis of autoantibodies in pemphigus using phage display

• Project/Area Number: 23791291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: YAMAGAMI Jun 慶應義塾大学, 医学部, 助教 (80327618)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 天疱瘡 / 自己抗体 / 自己免疫 / 自己免疫疾患 / 自己反応性B細胞

Research Abstract

Pemphigus is an autoimmune bullous disease caused by autoantibodies against desmoglein (Dsg), an adhesion molecule between keratinocytes. In this study, we tried to investigate autoantibodies against the precursor form of Dsg (preDsg) and the pathogenicit

Research Products

• [Journal Article] Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus (2013)
  • Author(s): Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Makni S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M
  • Journal Title: J Dermatol Sci Volume: 70(1) Issue: 1 Pages: 19-25
  • DOI: 10.1016/j.jdermsci.2013.02.002
  • Peer Reviewed
• [Journal Article] Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display (2012)
  • Author(s): Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M
  • Journal Title: J Invest Dermatol Volume: 132(4) Issue: 4 Pages: 1141-1148
  • DOI: 10.1038/jid.2011.449
  • Peer Reviewed
• [Presentation] Antibodies against desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus are mostly against the precursor molecule. (2012)
  • Author(s): Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Marki S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M
  • Organizer: The 75th Annual meeting of Society for Investigative Dermatology
  • Place of Presentation: ノースカロライナ州ローリー,米国)
  • Year and Date: 2012-05-09
• [Presentation] 風土病型落葉状天疱瘡の発症前におけるデスモグレイン1前駆体に対する抗体 (2012)
  • Author(s): 山上淳, Toumi A, Saleh MA, 蜂矢隆久, 黒田慶子, Stanley JR, Masmoudi H, 天谷雅行
  • Organizer: 第19回分子皮膚科学フォーラム
  • Place of Presentation: 青森
  • Year and Date: 2012-04-13
• [Presentation] Antibodies against desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus are mostly against the precursor molecule (2012)
  • Author(s): Jun Yamagami
  • Organizer: 2012 Society for Investigative Dermatology annual Meeting
  • Place of Presentation: Raleigh, North Carolina, USA