| Project/Area Number |
23791296
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
UEDA Ikuko 関西医科大学, 医学部, 助教 (80452100)
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| Project Period (FY) |
2011-04-28 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | サルコイドーシス / BAFF / B細胞 / 単球 / 自己抗体 |
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| Research Abstract |
The purpose of this study was to determine serum levels of B-cell-activating factor (BAFF) and its clinical association in patients with sarcoidosis.
Serum BAFF levels were significantly elevated in sarcoidosis patients when compared to healthy controls. The frequencies of skin and eye involvement were significantly higher in patients with elevated serum BAFF than in those patients with normal levels. Serum BAFF levels were correlated with serum levels of ACE, lysozyme, and IFN-gamma. Immunostaining of anti-BAFF in the skin revealed BAFF expression by epithelioid cells of granuloma. In vitro, IFN-gamma induced membrane-bound BAFF expression on monocytes and secretion of soluble BAFF by isolated monocytes. In conclusion, serum BAFF levels can be used as a surrogate marker of disease activity in sarcoidosis patients. Increased BAFF may be related to the pathogenesis of sarcoidosis.
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