Study on potentiation of neurite outgrowth by an atypical antipsychotic
| Project/Area Number |
23791308
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Chiba University |
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Principal Investigator |
ISHIMA Tamaki 千葉大学, 社会精神保健教育研究センター, 特任研究員 (00597130)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 精神薬理学 / 神経突起伸長 / アリピプラゾール / カルシウムシグナリング / 熱ストレスタンパク質 / IP3受容体 |
|---|
| Research Abstract |
Aripiprazole significantly potentiated nerve growth factor(NGF)-induced neurite outgrowth in PC12 cells, in a concentration-dependent manner. The 5-HT1A receptor antagonist WAY-100635, but not the dopamine D2 receptor antagonistsulpiride, blocked the effects of aripiprazole, although, only partially. Specificinhibitors of several common signaling pathways also blocked the effects of aripiprazole.Using proteomic analysis, we found that aripiprazole significantly increased levels ofthe heat shock protein Hsp90α in cultured cells.
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Report
(3 results)
Research Products
(5 results)
