Functional brain imaging and the longitudinal changes of depressive states in major psychiatric disorders
| Project/Area Number |
23791309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKIZAWA Ryu 東京大学, 医学部附属病院, 助教 (30420243)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 脳機能イメージング / 統合失調症 / 双極性障害 / うつ病 / 早期診断・早期治療 / 精神疾患の生物学的指標 / 症状評価・予後予測 / 臨床応用 / 近赤外線スペクトロスコピー(NIRS) / 気分障害 / 不安障害 / 鑑別診断補助 / 前頭葉機能 / 生物学的指標 / 近赤外線スペクトロスコピー（NIRS） / 精神疾患の生物学的指標（バイオマーカー） / うつ症状の鑑別診断補助 / 前頭葉 |
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| Research Abstract |
The main strengths of the study include the application of a neuroimaging biomarker in clinical practice that allows the clinically useful differential diagnosis, the assessment of symptoms, and the prognostic predictions. Some of our studies provided evidence that the fronto-temporal NIRS signal may be used as a tool in assisting the diagnosis of major psychiatric disorders and the assessment of symptoms. The current studies have shown the potential applicability of this method to the identification of a need for therapy, the assessment of the efficacy of various treatments, and the establishment of prognostic predictions. The availability of such a comprehensively visualized report to clinicians, patients and their caretakers at a first visit, while laying out a future treatment plan, would likely lead to a paradigm shift to a patient-centered approach in clinical psychiatry.
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Report
(4 results)
Research Products
(172 results)
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[Journal Article] Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals2014
Author(s)
Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Kawasaki S, Yamasue H, Tochigi M, Kakiuchi C, Sasaki T, Iwayama Y, Yamada K, Yoshikawa T, and Kasai K
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Journal Title
NeuroImage
Volume: 1
Pages: 527-34
DOI
Related Report
Peer Reviewed
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[Journal Article] A NIRS-fMRI investigation of prefrontal cortex activity during a working memory task2013
Author(s)
Sato H, Yahata, N, Funane T, Takizawa R, Katura T, Atsumori H, Nishimura Y, Kinoshita A, Kiguchi M, Koizumi H, Fukuda M, Kasai K.
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Journal Title
NeuroImage
Volume: 83
Pages: 158-73
Related Report
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[Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults2013
Author(s)
Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, and Kano Y
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Journal Title
Neuroimage : Clinical
Volume: 4
Pages: 53-63
DOI
Related Report
Peer Reviewed
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[Journal Article] A NIRS–fMRI investigation of prefrontal cortex activity during a working memory task.2013
Author(s)
Sato H, Yahata N, Funane T, Takizawa R, Katura T, Atsumori H, Nishimura Y, Kinoshita A, Kiguchi M, Koizumi H, Fukuda M, Kasai K
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Journal Title
Neuroimage
Volume: 83
Pages: 158-73
DOI
Related Report
Peer Reviewed
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[Journal Article] A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project2013
Author(s)
Koike, S., Takano, Y., Iwashiro, N., Satomura, Y., Suga, M., Nagai, T., Natsubori, T., Tada, M., Nishimura, Y., Yamasaki, S., Takizawa, R., Yahata, N., Araki, T., Yamasue, H. & Kasai, K
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Journal Title
Schizophr Res
Volume: 143(1)
Issue: 1
Pages: 116-24
DOI
Related Report
Peer Reviewed
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[Presentation] 光トポグラフィ2011
Author(s)
滝沢龍ら
Organizer
平成23年度国公私立大学病院医療技術関連職員研修
Place of Presentation
東京
Year and Date
2011-11-01
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