Research Project
Grant-in-Aid for Young Scientists (B)
BackgroundRecent studies showed that at-risk mental state (ARMS) patients and first-episode schizophrenia (FES) patients had reduced amplitudes of mismatch negativity (MMN) and P3a. However, duration and frequency MMN/P3a may reflect different pathophysiology in the early stages of schizophrenia. In this study, we investigated duration and frequency MMN and P3a in ARMS and FES.MethodsSubjects consisted of 20 FES patients, 21 ARMS patients, and 22 healthy controls (HC). We measured MMN / P3a to duration deviants and frequency deviants relative to standard tones. The ethical committee of the University of Tokyo Hospital approved this study.ResultsDuration MMN amplitude was significantly reduced in ARMS and FES compared to HC. Frequency MMN amplitudes were not significantly different among the three groups. Both duration P3a and frequency P3a amplitudes were significantly reduced in ARMS and FES compared to HC.ConclusionDuration MMN/P3a and frequency MMN/P3a have different patterns of deficits in theearly stages of schizophrenia. These findings suggest that duration and frequency MMN/P3a may provide complementary information in the early stages of schizophrenia. These ERP components could be a candidate for the biomarkers in schizophrenia.
All 2013 2012 2011 Other
All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (16 results) Book (1 results)
Schizophr Res
Volume: 146 Issue: 1-3 Pages: 336-43
10.1016/j.schres.2013.02.028
J Hum Genet
Volume: 58(2) Issue: 2 Pages: 91-7
10.1038/jhg.2012.140
10031156430
Volume: 143(1) Issue: 1 Pages: 116-24
10.1016/j.schres.2012.11.012
Prog Neuropsychopharmacol Biol Psychiatry.
Volume: 37 Issue: 2 Pages: 270-275
10.1016/j.pnpbp.2012.02.012
臨床精神医学
Volume: 41 Pages: 1363-1367
Volume: 41 Pages: 1427-1431
Volume: 41 Pages: 1465-1468
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 37 Pages: 270-275
Psychiatry Clin Neurosci
Volume: 65 Pages: 672-5
Volume: 65 Pages: 606-7
Volume: 132 Pages: 54-61
