Development of a method for diagnosis of the prodromal stage of schizophrenia

• Project/Area Number: 23791334
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Okayama University
• Principal Investigator: OKAHISA Yuko 岡山大学, 岡山大学病院, 助教 (90583097)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 統合失調症 / 遺伝子発現 / 臨床精神分子遺伝学 / ARMS

Research Abstract

The purpose of this study was to develop a method for diagnosisof schizophrenia in the prodromal stage. We evaluated the symptoms of eight subjects who were at risk of developing schizophrenia for one year. Then, we analyzed their whole-gene expression profiles using a microarray but failed to find any significant genome-wide difference between the groups that developed of schizophrenia and those who did not. A larger sample should be investigated in further studies.

Research Products

• [Journal Article] Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia (2011)
  • Author(s): Okahisa Y, Kodama M, Takaki M, Inada T,Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 190-4
  • Peer Reviewed
• [Journal Article] Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence (2011)
  • Author(s): Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 183-9
  • Peer Reviewed
• [Journal Article] Association study of serine racemase gene with methamphetamine psychosis (2011)
  • Author(s): Yokobayashi E, Ujike H, Kotaka T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 169-75
  • Peer Reviewed
• [Journal Article] Association Between 5HT1b Receptor Gene and Methamphetamine Dependence (2011)
  • Author(s): Ujike H, Kishimoto M, Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 163-8
  • Peer Reviewed
• [Presentation] Japanese Genetic Initiative for Drug Abuse (JGIDA) (2012)
  • Author(s): Ozaki N, Ujike H, Iwata N
  • Organizer: Shared Genetic Risk between Methamphetamine-induced Psychosis and Schizophrenia
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2012-10-17
• [Presentation] ASSOCIATION BETWEEN THE TYROSINE HYDROXYLASE GENE AND PATIENTS WITH METHAMPHETAMINE DEPENDENCE (2012)
  • Author(s): Okahisa Y, Kishimoto M, Sakamoto S, Kodama M, Takaki M, Won M, Kondo N, Naruse N, Uehara K, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Uchitomi Y
  • Organizer: 25th Congress of European college of neuropsychopharmacology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-10-14
• [Presentation] PCM1 遺伝子と統合失調症の関連解析 (2012)
  • Author(s): 酒本真次, 高木学, 岡久祐子, 水木寛, 児玉匡史, 氏家寛, 内富庸介
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-28
• [Presentation] 2 型糖尿病疾患候補遺伝子ARHGEF11 の統合失調症における相関解析 (2012)
  • Author(s): 水木寛, 高木学, 酒本真次, 岡久祐子, 児玉匡史, 氏家寛, 内富庸介
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-28
• [Presentation] Association between the Fyn kinase gene and patients with methamphetamine psychosis (2012)
  • Author(s): Okahisa Y, Sakamoto S, Kodama M, Takaki M, Won M, Kondo N, Naruse N, Uehara K, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Uchitomi Y
  • Organizer: 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2012-06-04
• [Presentation] 統合失調症と覚醒剤誘発性精神病の遺伝学的共通性 (2012)
  • Author(s): 池田匡志, 岡久祐子, 福生泰久, アレクシッチ・ブランコ, 尾崎紀夫, 岩田仲生
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-05-25
• [Presentation] シンポジウム 薬物依存の基礎から臨床、そして日常診療との関わりについて (2012)
  • Author(s): 岡久祐子
  • Organizer: 薬物乱用・依存の遺伝子研究 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-05-25
• [Presentation] A Polymorphism in the CNR1 Gene Is Associated with Gene Expression and Schizophrenia (2012)
  • Author(s): Okahisa Y, Ujike H, Kodama M, Takaki M, Mizuki Y, Sakamoto S, Imai N, Uchitomi Y, Arai M, Itokawa M
  • Organizer: 3rd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2012-04-15
• [Presentation] Association between the ARHGEF11 gene and Schizophrenia in a Japanese Population (2012)
  • Author(s): Mizuki Y, Takaki M, Okahisa Y, Kodama M, Ujike H, Uchitomi Y
  • Organizer: 3rd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2012-04-15
• [Presentation] Shared genetic risk between Methamphetamine-induced psychosis and schizophrenia (2011)
  • Author(s): 池田匡志、岡久祐子、福生泰久、氏家寛、岩田仲生
  • Organizer: 第56回日本人類遺伝学会・第11回東アジア人類遺伝学会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-11
• [Presentation] Japanese Genetic Initiative for Drug Abuse (2011)
  • Author(s): Ikeda M,Okahisa Y, Fukuo Y
  • Organizer: 2nd Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-09-23
• [Presentation] ASSOCIATION STUDY OF DOPAMINE ss-HYDROXYLASE GENE WITH METHAMPHETAMINE DEPENDENCE (2011)
  • Author(s): Okahisa Y, Ujike H, Kodama M, Takaki M, Kodama M, Takaki M, Mujun W, Kondo N, Naruse N, Iwata N, Iyo M, Sora I, Ozaki N, Uchitomi Y
  • Organizer: The Third Annual International Drug Abuse Research Society /International Society for Neruochemistry Satellite Meeting
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-08-23
• [Presentation] NMDA 受容体遺伝子サブユニット GRIN2B 遺伝子(GRIN2B)多型と覚せい剤精神病の関連 研究 (2011)
  • Author(s): 水木 寛 、氏家 寛、岡久祐子、高木 学 、元 武俊、近藤直樹、成瀬暢也、曽良一郎、岩田仲生、伊豫雅臣、尾崎紀夫、内富庸介
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-23
• [Presentation] 白血病阻害因子遺伝子は統合失調症および作業記憶に関連する (2011)
  • Author(s): 岡久祐子、功刀 浩、児玉匡史、高木 学、氏家 寛
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] Shared risk between Methamphetamine-induced psychosis and schizophrenia (2011)
  • Author(s): Ikeda M, Okahisa Y, Fukuo Y, Japanese Genetic Initiative for Drug Abuse (JGIDA), Ujike H, Iwata N
  • Organizer: 2nd Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: ソウル（韓国）