The relationship between the perioperative transition of serum anticholinergic activity and postoperative delirium among patients undergoing esophagectomy and gastrectomy

• Project/Area Number: 23791353
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Juntendo University
• Principal Investigator: HARA Atsuko 順天堂大学, 医学部, 助教 (00330861)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 術後せん妄 / 抗コリン活性 / 手術侵襲 / 炎症 / せん妄 / 高齢者 / 血清抗コリン活性 / 食道癌手術 / 胃切除術 / サイトカイン / 血清コリン活性 / I型インスリン様増殖因子

Research Abstract

We evaluated the changes in the levels of serum anticholinergic activity (SAA) during the pre- and postoperative periods, and investigated the relationship between the levels of SAA and the occurrence of postoperative delirium. Patients undergoing elective esophagectomy or gastrectomy under general anesthesia were prospectively studied. The levels of SAA were measured immediately before and after the surgery, then categorized into three groups, (+), () and (-) according to the results.Postoperative delirium was identified in 41.2% of the 34 patients enrolled in this study. The preoperatively SAA (+) patients who remained SAA (+) or SAA () after surgery were more likely to develop postoperative delirium. It was speculated that the cholinergic system failed to compensate for the elevation of the SAA level in patients who developed delirium.
In conclusion, the perioperative transition of the SAA levels may be associated with the occurrence of postoperative delirium.

Research Products

• [Journal Article] The relationship between the perioperative transition of serum anticholinergic activity and postoperative delirium in patients undergoing esophagectomy and gastrectomy (2014)
  • Author(s): Yuka Kitajima, Keisuke Yamaguchi, Koji Hori, Taisuke Murakami, Akimasa Someya, Kimiko Konishi, Atsuko Hara, Mitsugu Hachisu, Yoshiaki Kajiyama, Isao Nagaoka, Eiichi Inada
  • Journal Title: 順天堂醫事雑誌 Volume: 60 Pages: 1-4
  • NAID: 130004684332
  • Peer Reviewed
• [Journal Article] 超音波ガイド下頸動脈洞神経ブロックを用いて管理した二期的頸動脈ステント留置術の1症例 (2013)
  • Author(s): 森田善仁,原厚子,山口敬介,山本宗孝,大石英則,井関雅子,稲田英一
  • Journal Title: 麻酔62 Volume: 5 Pages: 613-618
  • NAID: 40019683113