Dopamine D1 receptor agonists may be useful therapeutic agents for the treatment of drug addiction and schizophrenia.
| Project/Area Number |
23791359
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬物依存、 / 統合失調症、 / ドーパミン、 / メタンフェタミン / 、コカイン / 薬物依存 / 統合失調症 / ドーパミン / コカイン |
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| Research Abstract |
Chronic activation of dopamine D1 receptors induces the persistent reversal ofbehavioral sensitization to methamphetamine. The biochemical analyses s u g g e s t t h a t chronic dopamine D1 receptor agonism adjusts the enhanced dopamine D1 receptorsignaling in the striatum of methamphetamine-sensitized rats. The study providesexperimental evidence that dopamine D1 receptor agonists may be useful aspharmacotherapeutic agents for the treatment of drug addiction and schizophrenia
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Report
(3 results)
Research Products
(12 results)
