| Project/Area Number |
23791376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
NAM JinMin 北海道大学, 大学院・医学研究科, 特任助教 (60414132)
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| Research Collaborator |
ONODERA Yasuhito 北海道大学, 大学院・医学研究科, 助教 (90435561)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 放射線 / 乳癌 / 浸潤 / インテグリン / 3次元培養 |
|---|
| Research Abstract |
Radiation therapy is the common treatment for breast cancer, and the primary goal of therapy is to prevent invasive recurrence. The detailed molecular mechanism of invasive recurrence after radiation therapy is not well understood. This study investigated the effect of radiation on a three-dimensional culture model of non-invasive breast cancer, and identified important molecule and possible molecular mechanism underlying emergence of invasiveness. Our results suggest that α5ss1-integrin via NF-κB signaling is an important mediator of invasive progression after radiation treatment on non-invasive breast cancer cells in three-dimensional extracellular matrix.
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