| Project/Area Number |
23791389
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences (2012-2013)
Yamagata University (2011) |
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Principal Investigator |
NOMIYA Takuma 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 医長 (60436201)
|
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| Research Collaborator |
NEMOTO Kenji 山形大学, 医学部医学系研究科, 教授
KANEKO Takashi 山形大学, 医学部医学科
GOTO Jun 山形大学, 医学部医学科
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 放射線治療生物学 / 放射線障害 / フリーラジカル / 酸化ストレス / 動物実験 / 放射線照射 / 皮膚反応 / 放射線 |
|---|
| Research Abstract |
Recently, oxidative metabolites have been able to be measured by simple small device. Radiation used in radiotherapy causes free radicals and oxidative metabolites, and irradiation causes dermatitis and sometimes causes skin ulcer in the irradiated site. We analyzed the relationships among the value of oxidative metabolites and skin reactions and gene expressions. As a result, a significant correlation was seen between the value of oxidative metabolites and irradiation dose. And some genes (e.g. NOS2, NCF1, NCF2, etc.) were overexpressed after the irradiation. It was suggested that measuring the level of serum oxidative metabolites seems to be useful for estimating degree of skin reaction, and a part of reactions to the irradiation was revealed in the gene expression level.
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