Development of an innovative system for cancer diagnosis and therapy; from diagnosis and therapy for bone metastases to DDS

• Project/Area Number: 23791401
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: OGAWA Kazuma 金沢大学, 薬学系, 准教授 (30347471)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: DDS / ナノパーティクル / セラノスティクス / PET

Research Abstract

Drug delivery system (DDS), which is for delivery of anticancer drugs to cancer tissue, is very important because it enhances the therapeutic effects and reduces the side effects. The aim of this study is development of a DDS using hydroxyapatite as a nanoparticle carrier. A novel cancer diagnosis and therapy DDS, which is a conjugation between a radiolabeled compound with high bone affinity and hydroxyapatite, was synthesized and evaluated.

Research Products

• [Journal Article] Bone target radiotracers for palliative therapy of bone metastases (2012)
  • Author(s): K. Ogawa and K. Washiyama
  • Journal Title: Current Medicinal Chemistry Volume: 19 Pages: 3290-3300
  • Peer Reviewed
• [Journal Article] Advances in Drug Design of Radiometal-Based Imaging Agents for Bone Disorders (2011)
  • Author(s): K. Ogawa and H. Saji
  • Journal Title: International Journal of Molecular Imaging Volume: 2011 Pages: 537687-537687
  • DOI: 10.1155/2011/537687
  • Peer Reviewed
• [Journal Article] Preparation and evaluation of aradiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent (2011)
  • Author(s): Ogawa K., Takai K., Kanbara H., KiwadaT., Kitamura Y., Shiba K. and Odani A.
  • Journal Title: Nuclear Medicine and Biology Volume: 38 Issue: 5 Pages: 631-636
  • DOI: 10.1016/j.nucmedbio.2010.12.004
  • Peer Reviewed
• [Presentation] Recent basic researches in radionuclide therapy in Japan (2011)
  • Author(s): K. Ogawa
  • Organizer: The 5th Japna-Korea-China Conference on Nuclear Medicine
  • Place of Presentation: International Congress Center (Ibaragi)
  • Year and Date: 2011-10-27
• [Presentation] Comparative study of biodistribution of alpha-emitting bone-seeking radiopharmaceuticals (2011)
  • Author(s): K. Wahiyama, K. Ogawa, S. Kinuya, R. Amano
  • Organizer: The 5th Japna-Korea-China Conference on Nuclear Medicine
  • Place of Presentation: International Congress Center (Ibaragi)
  • Year and Date: 2011-10-27
• [Presentation] Preparation and evaluation of radiogallium-DOTA complex conjugated acidic oligopeptide as bone imaging agents. (2011)
  • Author(s): K. Takai, K. Ogawa, T. Kiwada, Y.Kitamura, K. Shiba, A. Odani
  • Organizer: The 5th Japan-Korea-China Conference on Nuclear Medicine
  • Place of Presentation: International Congress Center (Ibaragi)
  • Year and Date: 2011-10-27
• [Presentation] 転移性骨腫瘍の診断を目的とした放射性ガリウム標識薬剤の開発 (2011)
  • Author(s): 高井健一郎、小川数馬、黄檗達人、北村陽二、柴和弘、小谷明
  • Organizer: 第9回次世代を担う若手のフィジカル・ファーマフォーラム
  • Place of Presentation: ホテル箱根アカデミー (神奈川)
  • Year and Date: 2011-09-12
• [Presentation] Development of radiogallium-DOTA complex conjugated acidic oligopeptides for bone imaging. (2011)
  • Author(s): K. Takai, K. Ogawa, T. Kiwada, Y. Kitamura, K. Shiba, A. Odani
  • Organizer: The Society of Nuclear Medicine 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center (USA)