• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of an innovative system for cancer diagnosis and therapy; from diagnosis and therapy for bone metastases to DDS

Research Project

Project/Area Number 23791401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

OGAWA Kazuma  金沢大学, 薬学系, 准教授 (30347471)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsDDS / ナノパーティクル / セラノスティクス / PET
Research Abstract

Drug delivery system (DDS), which is for delivery of anticancer drugs to cancer tissue, is very important because it enhances the therapeutic effects and reduces the side effects. The aim of this study is development of a DDS using hydroxyapatite as a nanoparticle carrier. A novel cancer diagnosis and therapy DDS, which is a conjugation between a radiolabeled compound with high bone affinity and hydroxyapatite, was synthesized and evaluated.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Bone target radiotracers for palliative therapy of bone metastases2012

    • Author(s)
      K. Ogawa and K. Washiyama
    • Journal Title

      Current Medicinal Chemistry

      Volume: 19 Pages: 3290-3300

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advances in Drug Design of Radiometal-Based Imaging Agents for Bone Disorders2011

    • Author(s)
      K. Ogawa and H. Saji
    • Journal Title

      International Journal of Molecular Imaging

      Volume: 2011 Pages: 537687-537687

    • DOI

      10.1155/2011/537687

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and evaluation of aradiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent2011

    • Author(s)
      Ogawa K., Takai K., Kanbara H., KiwadaT., Kitamura Y., Shiba K. and Odani A.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 38 Issue: 5 Pages: 631-636

    • DOI

      10.1016/j.nucmedbio.2010.12.004

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Recent basic researches in radionuclide therapy in Japan2011

    • Author(s)
      K. Ogawa
    • Organizer
      The 5th Japna-Korea-China Conference on Nuclear Medicine
    • Place of Presentation
      International Congress Center (Ibaragi)
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparative study of biodistribution of alpha-emitting bone-seeking radiopharmaceuticals2011

    • Author(s)
      K. Wahiyama, K. Ogawa, S. Kinuya, R. Amano
    • Organizer
      The 5th Japna-Korea-China Conference on Nuclear Medicine
    • Place of Presentation
      International Congress Center (Ibaragi)
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Preparation and evaluation of radiogallium-DOTA complex conjugated acidic oligopeptide as bone imaging agents.2011

    • Author(s)
      K. Takai, K. Ogawa, T. Kiwada, Y.Kitamura, K. Shiba, A. Odani
    • Organizer
      The 5th Japan-Korea-China Conference on Nuclear Medicine
    • Place of Presentation
      International Congress Center (Ibaragi)
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 転移性骨腫瘍の診断を目的とした放射性ガリウム標識薬剤の開発2011

    • Author(s)
      高井健一郎、小川数馬、黄檗達人、北村陽二、柴和弘、小谷明
    • Organizer
      第9回次世代を担う若手のフィジカル・ファーマフォーラム
    • Place of Presentation
      ホテル箱根アカデミー (神奈川)
    • Year and Date
      2011-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of radiogallium-DOTA complex conjugated acidic oligopeptides for bone imaging.2011

    • Author(s)
      K. Takai, K. Ogawa, T. Kiwada, Y. Kitamura, K. Shiba, A. Odani
    • Organizer
      The Society of Nuclear Medicine 58th Annual Meeting
    • Place of Presentation
      San Antonio Convention Center (USA)
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi