Optimization of synthesis methods and synthesis condition in C-11 labeling

• Project/Area Number: 23791420
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: KANAI Yasukazu 大阪大学, 大学院・医学系研究科, 寄附講座助教 (60397643)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: PET / 標識合成 / Loop 法 / オンカラム法 / 比放射能 / 炭素11 / 国際情報交流

Research Abstract

In this study, I have investigated about synthesis methods of Carbon -11 labeled PET ligand. I have revealed feature of each synthesis method by confirmingradioactivity of final products, specific activity synthesis method and so on with compare gas phase reaction and liquid phase reaction, bubbling method and liquid phase reaction or bubbling method and on-column methods

Research Products

• [Presentation] Comparison of 11C labeling methods (2013)
  • Author(s): Kanai Yasukazu, Watabe Hiroshi, Naka Sadahiro, Miyake Yoshinori, Kato Hiroki, Isohashi Kayako, Shimosegawa Eku, Hatazawa Jun
  • Organizer: International Symposium on Radiopharmaceutical Science
  • Place of Presentation: Jeju, South Korea
• [Presentation] Comparison of 11C labeling methods (2013)
  • Author(s): Yasukazu Kanai
  • Organizer: The 20th lnternational Symposiurn on Radiopharrnaceutical Sciences
  • Place of Presentation: Jeju, South Korea
• [Presentation] 臨床使用に向けた11C-DPA713標識合成方法の最適化 (2012)
  • Author(s): 仲定宏、金井泰和、木下大輔、松浦邦広、加藤弘樹、下瀬川恵久、畑澤順
  • Organizer: 日本薬学会 第132年会
  • Place of Presentation: 札幌