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T1rho MR imaging for the evaluation of the denaturelizatoin of articular cartilage caused by osteoarthritis

Research Project

Project/Area Number 23791431
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

TAKAYAMA Yukihisa  九州大学, 医学(系)研究科(研究院), 助教 (60546563)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords変形性膝関節症 / MRI / T1ρ / 関節軟骨 / 膝関節 / 膝 / T1ρ(rho) / 磁気共鳴画像 / T2 / 軟骨 / Tρ(T1rho) / 関節リウマチ / 軟骨変性
Research Abstract

T1rho mapping is one of the quantitative MR imaging techniques for the assessment of articular cartilage, because it can quantitatively evaluate the contents of extracellular matrices, such as collagen and proteoglycan (PG), in the cartilage. At the early stage of osteoarthritis (OA), PG depletion occurs prior to the decrease in collagen. It is presumed that T1rho mapping is sensitive enough to detect PG depletion at the early stage of OA. Therefore, we evaluated the clinical utility of T1rho mapping as a diagnostic tool in patients with OA by comparing with T2 mapping which is widely used in clinical practice. We compared T1rho and T2 mappings for their ability to differentiate between normal and denatured articular cartilage by means of radiological-histological correlation. We concluded that T1rho mapping is superior to T2 mapping for the evaluation of denatured articular cartilage with osteoarthritis of the knee.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] T1ρis superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis : Radiological-pathological correlation after total knee arthroplasty2013

    • Author(s)
      Takayama Y, Hatakenaka M, Tsushima H, Okazaki K, Yoshiura T, Yonezawa M, Nishikawa K, Iwamoto Y, Honda H
    • Journal Title

      Eur J Radiol

      Volume: 82(4) Issue: 4 Pages: e192-e198

    • DOI

      10.1016/j.ejrad.2012.11.031

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of cartilage degradation in arthritis using T1ρ magnetic resonance imaging mapping2012

    • Author(s)
      Tsushima H, Okazaki K, Takayama Y, Hatakenaka M, Honda H, Izawa T, Nakashima Y, Yamada H, Iwamoto Y
    • Journal Title

      Rheumatology international

      Volume: 32 Issue: 9 Pages: 2867-2875

    • DOI

      10.1007/s00296-011-2140-3

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Assessment of T1ρand T2 mapping as biomarkers of denaturalization in articular cartilage with osteoarthritis : comparison with pathological results after total knee replacement2011

    • Author(s)
      Takayama Y, Hatakenaka M, Yoshiura T, Tsushima H, Okazaki K, Nishikawa K, Obara M, Iwamoto Y, Honda H.
    • Organizer
      ISMRM 19th Annual Meeting & Exhibition
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] T1ρとT2マップは変形性膝関節症の関節軟骨変性評価の有用性;術後標本との対比2011

    • Author(s)
      Takayama Y, Hatakenaka M, Yoshiura T, et al.
    • Organizer
      20th annual meeting of ISMRM
    • Place of Presentation
      モントリオール、ケベック州、カナダ
    • Related Report
      2011 Research-status Report
  • [Book] 機能画像を得るための工夫 1.T1ρ, T2* Mapの使い方、使い分け2012

    • Author(s)
      高山 幸久 他
    • Total Pages
      4
    • Publisher
      インナービジョン社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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