T1rho MR imaging for the evaluation of the denaturelizatoin of articular cartilage caused by osteoarthritis

• Project/Area Number: 23791431
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: TAKAYAMA Yukihisa 九州大学, 医学(系)研究科(研究院), 助教 (60546563)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 変形性膝関節症 / MRI / T1ρ / 関節軟骨 / 膝関節 / 膝 / T1ρ(rho) / 磁気共鳴画像 / T2 / 軟骨 / Tρ(T1rho) / 関節リウマチ / 軟骨変性

Research Abstract

T1rho mapping is one of the quantitative MR imaging techniques for the assessment of articular cartilage, because it can quantitatively evaluate the contents of extracellular matrices, such as collagen and proteoglycan (PG), in the cartilage. At the early stage of osteoarthritis (OA), PG depletion occurs prior to the decrease in collagen. It is presumed that T1rho mapping is sensitive enough to detect PG depletion at the early stage of OA. Therefore, we evaluated the clinical utility of T1rho mapping as a diagnostic tool in patients with OA by comparing with T2 mapping which is widely used in clinical practice. We compared T1rho and T2 mappings for their ability to differentiate between normal and denatured articular cartilage by means of radiological-histological correlation. We concluded that T1rho mapping is superior to T2 mapping for the evaluation of denatured articular cartilage with osteoarthritis of the knee.

Research Products

• [Journal Article] T1ρis superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis : Radiological-pathological correlation after total knee arthroplasty (2013)
  • Author(s): Takayama Y, Hatakenaka M, Tsushima H, Okazaki K, Yoshiura T, Yonezawa M, Nishikawa K, Iwamoto Y, Honda H
  • Journal Title: Eur J Radiol Volume: 82(4) Issue: 4 Pages: e192-e198
  • DOI: 10.1016/j.ejrad.2012.11.031
  • Peer Reviewed
• [Journal Article] Evaluation of cartilage degradation in arthritis using T1ρ magnetic resonance imaging mapping (2012)
  • Author(s): Tsushima H, Okazaki K, Takayama Y, Hatakenaka M, Honda H, Izawa T, Nakashima Y, Yamada H, Iwamoto Y
  • Journal Title: Rheumatology international Volume: 32 Issue: 9 Pages: 2867-2875
  • DOI: 10.1007/s00296-011-2140-3
  • Peer Reviewed
• [Presentation] Assessment of T1ρand T2 mapping as biomarkers of denaturalization in articular cartilage with osteoarthritis : comparison with pathological results after total knee replacement (2011)
  • Author(s): Takayama Y, Hatakenaka M, Yoshiura T, Tsushima H, Okazaki K, Nishikawa K, Obara M, Iwamoto Y, Honda H.
  • Organizer: ISMRM 19th Annual Meeting & Exhibition
  • Place of Presentation: Montreal, Quebec, Canada
• [Presentation] T1ρとT2マップは変形性膝関節症の関節軟骨変性評価の有用性；術後標本との対比 (2011)
  • Author(s): Takayama Y, Hatakenaka M, Yoshiura T, et al.
  • Organizer: 20th annual meeting of ISMRM
  • Place of Presentation: モントリオール、ケベック州、カナダ
• [Book] 機能画像を得るための工夫 1．T1ρ, T2* Mapの使い方、使い分け (2012)
  • Author(s): 高山 幸久 他
  • Total Pages: 4
  • Publisher: インナービジョン社