| Project/Area Number |
23791436
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アミロイド / 糖尿病 / アミロイドイメージング / アミロイドイメーイング / FDG-PET |
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| Outline of Final Research Achievements |
The number of patients with diabetes including pre-clinically diabetes, has estimated 22 million people at the time in 2007. And it become clear that the prevalence of Alzheimer's disease (AD) of those people, is higher than healthy individuals. Recently, amyloid imaging that image amyloid β protein in the brain, have developed and expected to become possible presymptomatic diagnosis of AD.
In this study, we performed PiB-PET imaging to 7 diabetic people and 13 non-diabetic people, then calculate distribution volume ratio of the cerebral cortex. PiB index of the diabetes group was 1.12 ± 0.07, and 1.10 ± 0.06 in the control group. There was no significant difference in both group. However, there is possibility that the limited number of cases and high PiB accumulation of elderly people affect the result.
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