Differences of the amyloid accumulation of PET study between diabetes and normal controls.

• Project/Area Number: 23791436
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MATSUSHIMA Shigenori 京都府立医科大学, 医学(系)研究科(研究院), 助教 (70535575)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: アミロイド / 糖尿病 / アミロイドイメージング / アミロイドイメーイング / FDG-PET

Outline of Final Research Achievements

The number of patients with diabetes including pre-clinically diabetes, has estimated 22 million people at the time in 2007. And it become clear that the prevalence of Alzheimer's disease (AD) of those people, is higher than healthy individuals. Recently, amyloid imaging that image amyloid β protein in the brain, have developed and expected to become possible presymptomatic diagnosis of AD.
In this study, we performed PiB-PET imaging to 7 diabetic people and 13 non-diabetic people, then calculate distribution volume ratio of the cerebral cortex. PiB index of the diabetes group was 1.12 ± 0.07, and 1.10 ± 0.06 in the control group. There was no significant difference in both group. However, there is possibility that the limited number of cases and high PiB accumulation of elderly people affect the result.

Research Products

• [Journal Article] Distribution of Amyloid Burden Differs between Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease (2013)
  • Author(s): Kondo M, Tokuta T, Itsukage M, Kuriyama N, Matsushima S, Yamada K, Nakanishi H, Ishikawa M, Nakagawa M
  • Journal Title: The Neuroradiology Journal Volume: 3 Pages: 129-134
  • Peer Reviewed
• [Journal Article] New semi-quantitative 123I-MIBG estimation method compared with scoring system in follow-up of advanced neuroblastoma: utility of total MIBG retention ratio versus scoring method. (2012)
  • Author(s): Sano Y, Okuyama C, Iehara T, Matsushima S, Yamada K, Hosoi H, Nishimura T.
  • Journal Title: Annals Nuclear Medicine Volume: 26 Pages: 462-70
  • NAID: 10030949416
  • Peer Reviewed
• [Journal Article] Utility of additional delayed post-therapeutic I-131 whole-body scanning in patients with thyroid cancer. (2012)
  • Author(s): Kodani N, Okuyama C, Aibe N, Matsushima S, Yamazaki H.
  • Journal Title: Clinical Nuclear Medicine Volume: 37 Pages: 264-7
  • Peer Reviewed
• [Journal Article] Simultaneous impairment of intracranial and peripheral artery vasoreactivity in CADASIL patients. (2012)
  • Author(s): Fujiwara Y, Mizuno T, Okuyama C, Nagakane Y, Watanabe-Hosomi A, Kondo M, Kuriyama N, Tokuda T, Matsushima S, Nishimura T, Nakagawa M.
  • Journal Title: Cerebrovascular disease Volume: 33 Pages: 128-34
  • Peer Reviewed