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Fundamental investigation about nephrogenic systemic fibrosis (NSF)and gadolinium-based MRI contrast agents

Research Project

Project/Area Number 23791458
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKawasaki Medical School

Principal Investigator

WATANABE Shigeru  川崎医科大学, 医学部, 講師 (20368640)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords放射性医薬品・造影剤 / 腎性全身性線維症 / Gd-EOB-DTPA / NSF / ガドリニウム / MRI / Gd-DTPA-BMA
Research Abstract

We have succeeded in quantification and visualization for gadolinium deposition in major organs by applying renal impaired rats were administered each gadolinium-based MRI contrast agent. Also, we can assess the association between nephrogenic systemic fibrosis and each MRI contrast agent including histopathological examination. In additional experiments using hepatorenally impaired rats, and investigated about the risk of nephrogenic systemic fibrosis, including the histopathological examination and gadolinium deposition in major organs for liver-specific MRI contrast agent.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2012 2011 Other

All Presentation (6 results)

  • [Presentation] 肝腎障害ラットにおけるGd-EOB-DTPA曝露後の組織内Gd沈着に関する基礎的検討2012

    • Author(s)
      佐藤朋宏
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都府京都市左京区宝が池
    • Year and Date
      2012-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝腎障害ラットにおけるGd-EOB-DTPA 曝露後の組織内Gd沈着に関する基礎的検討2012

    • Author(s)
      佐藤朋宏
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tissue gadolinium deposition in renally impaired rats exposed to Gd-EOB-DTPA and other gadolinium-based MRI contrast agents: Evaluation with inductively coupled plasma mass spectrometry (ICP-MS) and high resolution synchrotron fluorescent X-ray2011

    • Author(s)
      佐藤朋宏
    • Organizer
      第97回北米放射線学会
    • Place of Presentation
      アメリカ、シカゴ
    • Year and Date
      2011-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎性全身性線維症(NSF)とガドリニウム系MRI造影剤に関する基礎的検討2011

    • Author(s)
      佐藤朋宏
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      福岡県北九州市小倉
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Tissue gadolinium deposition in renally impaired rats exposed to Gd-EOB-DTPA and other gadolinium-based MRI contrast agents: Evaluation with inductively coupled plasma mass spectrometry (ICP-MS) and high resolution synchrotron fluorescent X-ray

    • Author(s)
      佐藤朋宏
    • Organizer
      第97回北米放射線学会
    • Place of Presentation
      McCormic Place(米国,シカゴ)
    • Related Report
      2011 Research-status Report
  • [Presentation] 腎性全身性線維症(NSF)とガドリニウム系MRI造影剤に関する基礎的検討

    • Author(s)
      佐藤朋宏
    • Organizer
      第39回日本磁気共鳴医学会大会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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