Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Research Abstract |
A monkey was developed very severe motor dysfunction after treatment of MPTP (1 mg/kg). In this state, dopamine transporter binding in the striatum measured by PET was reduced to about 5% of MPTP pretreatment level. Although it became difficult to assess the executive function, it was suggested the need to make a prior assessment of individual sensitivity to MPTP or consider the development of PD model using repetitive treatment of lower doses of MPTP.
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