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In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's disease

Research Project

Project/Area Number 23791469
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

NAGAI Yuji  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20415409)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords核医学(PETを含む) / パーキンソン病 / 遂行機能障害 / ポジトロンCT / ドーパミン受容体
Research Abstract

A monkey was developed very severe motor dysfunction after treatment of MPTP (1 mg/kg). In this state, dopamine transporter binding in the striatum measured by PET was reduced to about 5% of MPTP pretreatment level. Although it became difficult to assess the executive function, it was suggested the need to make a prior assessment of individual sensitivity to MPTP or consider the development of PD model using repetitive treatment of lower doses of MPTP.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: A positron emission tomography study2012

    • Author(s)
      Yuji Nagai, Takafumi Minamimoto, Kiyoshi Ando, Shigeru Obayashi, Hiroshi Ito, Nobuhiko Ito, Tetsuya Suhara
    • Journal Title

      Neuroscience research

      Volume: 73巻 Issue: 1 Pages: 61-67

    • DOI

      10.1016/j.neures.2012.02.007

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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