In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's disease

Research Project

Project/Area Number	23791469
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	National Institute of Radiological Sciences
Principal Investigator	NAGAI Yuji 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20415409)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	核医学(PETを含む) / パーキンソン病 / 遂行機能障害 / ポジトロンCT / ドーパミン受容体
Research Abstract	A monkey was developed very severe motor dysfunction after treatment of MPTP (1 mg/kg). In this state, dopamine transporter binding in the striatum measured by PET was reduced to about 5% of MPTP pretreatment level. Although it became difficult to assess the executive function, it was suggested the need to make a prior assessment of individual sensitivity to MPTP or consider the development of PD model using repetitive treatment of lower doses of MPTP.