Identification of stromal cells that have suppressive role againstpancreatic cancer cells and development of new anticancer therapy
| Project/Area Number |
23791544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MORIYAMA Taiki 九州大学, 医学研究院, 共同研究員 (70586859)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膵癌 / 膵星細胞 / CD271 |
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| Research Abstract |
The aim of the present study was to identify subpopulation of stromal cells that suppresspancreatic cancer cells. We analyzed surface marker of pancreatic stellate cells(PSCs) derived from human pancreatic ductal adenocarcinoma(PDAC), and characterized CD271+ PSCs.Quantitative RT-PCR analyses revealed that CD271 mRNA expression was increased in PSCs after coculture with pancreatic cancer cells. However, the level of CD271 mRNA expressionsubsequently decreased after the transient increase. Furthermore, CD271 mRNA expression was decreased in PSCs migrating toward pancreatic cancer cells through Matrigel.Immunohistochemistry of PDAC revealed stromal CD271 high expression was associated with a good prognosis. These findings suggest that CD271+ PSCs appear at the early stage ofpancreatic carcinogenesis and have suppressive role against pancreatic cancer cells through cancer-stromal interaction
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Report
(3 results)
Research Products
(13 results)
