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Clinical anatomical study for heart valve surgery

Research Project

Project/Area Number 23791579
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thoracic surgery
Research InstitutionToho University

Principal Investigator

KAWASHIMA Tomokazu  東邦大学, 医学部, 講師 (00328402)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords臨床解剖学 / 心臓自律神経系 / 刺激伝導系 / 画像解剖学 / 心臓血管外科学 / 比較進化解剖学 / 臨床解剖 / 比較解剖 / 心臓神経 / 弁膜症 / 米国 / 画像解剖
Outline of Final Research Achievements

The main aim of this research project is to formulate the clinical anatomical evidences on function-preserving operations aimed at improving patient quality of life for the heart valve diseases.
I showed that (1) the anatomical merits and demerits of new transcatheter aortic valve implantation (TAVI) and conventional surgical aortic valve replacement, (2) the individual diversity and relationship with the surrounding structures of the extrinsic autonomic cardiac nervous system and intrinsic cardiac conduction system, and (3) the basic data to help understand and translate the functional experimental findings to humans for future human clinical application. My clinical anatomical data would be contributed to the heart valve surgery.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Quantitative Analysis of Development and Aging of Genital Corpuscles in Glans Penis of the Rat.2015

    • Author(s)
      Shiino M, Hoshi H, Kawashima T, Ishikawa Y, Takayanagi M, Murakami K, Kishi K, Sato F
    • Journal Title

      Tissue Cell

      Volume: 47 Pages: 27-32

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing anatomical evidences on atrioventricular conduction system for TAVI.2014

    • Author(s)
      Kawashima T, Sato F
    • Journal Title

      International Journal of Cardiology

      Volume: 174 Issue: 1 Pages: 1-6

    • DOI

      10.1016/j.ijcard.2014.04.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 心臓の自律神経支配に関するマクロ解剖2014

    • Author(s)
      川島友和、星秀夫、佐藤二美
    • Journal Title

      Clinical Nueroscience

      Volume: 32 Pages: 1352-1353

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Systematic and comparative morphologies of the extrinsic cardiac nervous system in lemurs (Primates: Strepsirrhini: Infraorder Lemuriformes, Gray 1821) with evolutionary morphological implications2013

    • Author(s)
      Tomokazu Kawashima, Richard W. Thorington Jr., and Fumi Sato
    • Journal Title

      Zoologischer Anzeiger (J Comp Zool)

      Volume: 252 Issue: 1 Pages: 101-117

    • DOI

      10.1016/j.jcz.2012.04.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evolutionary anatomy and phyletic implication of the extrinsic cardiac nervous system in the Philippine tarsier (Tarsius syrichata, Primates) in comparisons with Strepsirrhines and New World monkeys2013

    • Author(s)
      Tomokazu Kawashima, Richard W. Thorington Jr., Kunio Murakami, and Fumi Sato
    • Journal Title

      Anatomical Record

      Volume: 296 Issue: 5 Pages: 798-806

    • DOI

      10.1002/ar.22680

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detailed comparative anatomy of the extrinsic cardiac nerve plexus and postnatal reorganization of the cardiac position and innervation in the great apes: orangutans, gorillas, and chimpanzees.2012

    • Author(s)
      Kawashima T and Sato F
    • Journal Title

      Anatomical Record

      Volume: 295 Issue: 3 Pages: 438-453

    • DOI

      10.1002/ar.21530

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evolutionary transformation of the Cervicobrachial Plexus in the Colugo (Cynocephalidae: Dermoptera) with a comparison to treeshrews (Tupaiidae: Scandentia) and strepsirrhines (Strepsirrhini: Primates) ~What is the most important factor related to the specialised morphology of the cervicobrachial plexus in the colugo: its gliding locomotion, phylogenetic constraint, or semi-elongated neck?~.2012

    • Author(s)
      Kawashima T, Murakami K, Takayanagi M, and Sato F
    • Journal Title

      Folia Morphologica

      Volume: 71 Pages: 228-239

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anatomical architecture of the brachial plexus in the common hippopotamus (Hippopotamus amphibious) with special reference to the derivation and course of its unique branches.2012

    • Author(s)
      Yoshitomi S, Kawashima T, Murakami K, Takayanagi M, Inoue Y, Aoyagi R, and Sato F
    • Journal Title

      Anatomia Histologia Embryologia

      Volume: 41 Issue: 4 Pages: 280-285

    • DOI

      10.1111/j.1439-0264.2012.01135.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anatomy of the Cardiac Nervous System with Clinical and Comparative Morphological Implications.2011

    • Author(s)
      Tomokazu Kawashima
    • Journal Title

      Anatomical Science International

      Volume: 86 Pages: 30-49

    • NAID

      10031162234

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human gross anatomy of cardiac conduction system with comparative morphological and developmental implications for human application.2011

    • Author(s)
      Tomokazu Kawashima and Hiroshi Sasaki
    • Journal Title

      Annals of Anatomy

      Volume: 193 Pages: 1-12

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative morphological configuration of the cardiac nervous system in lorises and galagos (Lorisiformes, Strepsirrhini, Primate) with evolutionary perspective.2011

    • Author(s)
      Tomokazu Kawashima and Richard W. Thorington Jr.
    • Journal Title

      Anatomical Record

      Volume: 294 Pages: 412-426

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Quantitative analysis of development and aging of genital corpuscles in glans penis of the rat.2015

    • Author(s)
      Shiino M, Ishikawa Y, Takayanagi M, Murakami M, Kishi K, Hoshi H, Kawashima T, Kiyoshi Kishi, Fumi Sato
    • Organizer
      120th Annual Meeting of The Japanese Association of Anatomists
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] New conduction abnormalities after TAVI: anatomical evaluation and strategy.2014

    • Author(s)
      Kawashima T, Hoshi H, Sakai M, Sato F
    • Organizer
      Joint Meeting of 2nd Asian Association of Clinical Anatomy and 18th Japanese Research Society of Clinical Anatomy
    • Place of Presentation
      Tokyo Medical &Dental Univ. (Bunkyo-ku, Tokyo)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 三尖弁形成術における機能温存のための臨床解剖学的検討2014

    • Author(s)
      川島友和、村上邦夫
    • Organizer
      第141回東邦医学会例会
    • Place of Presentation
      東邦大学(東京・大田区)
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大型類人猿心臓の自律神経分布に関する比較形態とその生後変化について2012

    • Author(s)
      川島友和 村上邦夫 高柳雅朗 井上由理子 石川陽一 佐藤二美
    • Organizer
      第117回日本解剖学会全国学術集会
    • Place of Presentation
      山梨県甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] 三尖弁形成術における機能温存のための臨床解剖学的検討

    • Author(s)
      川島友和、村上邦夫
    • Organizer
      第141回東邦医学会例会
    • Place of Presentation
      東邦大学医学部(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 上行大動脈周囲構造に関する臨床解剖学的検討

    • Author(s)
      川島友和、村上邦夫、清水一彦、星秀夫、酒井真、 石川陽一、佐藤二美
    • Organizer
      第119回日本解剖学会全国学術集会
    • Place of Presentation
      自治医科大学(栃木県)
    • Related Report
      2013 Research-status Report
  • [Presentation] キンギョ網膜が行う高次視覚情報処理を生み出す神経回路網の解析

    • Author(s)
      星秀夫、川島友和、村上邦夫、高柳雅朗、酒井真、石川陽一、佐藤二美
    • Organizer
      第119回日本解剖学会全国学術集会
    • Place of Presentation
      自治医科大学(栃木県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 大動脈弁置換術における機能温存のための臨床解剖学的解析

    • Author(s)
      川島友和、村上邦夫
    • Organizer
      第141回東邦医学会例会
    • Place of Presentation
      東邦大学(東京)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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