New therapeutic strategy with SMTP for acute cerebral ischemia

Research Project

Project/Area Number	23791582
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cerebral neurosurgery
Research Institution	Tohoku University
Principal Investigator	SAITO Atsushi 東北大学, 医学系研究科, 非常勤講師 (60375053)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	実験脳外科学 / 脳梗塞 / 国際情報交流
Research Abstract	We evaluated effectiveness of SMTP for acute cerebral ischemia using mouse transient focal cerebral ischemia model. SMTP was intravenously injected and successfully reduced size of cerebral infarction compared with the vehicle group. Cerebral blood flow analysis demonstrated that SMTP reduced remarkable increase of CBF after reperfusion and induced gradual CBF recovery. Superoxide production, radical reactive production and endothelial destruction marker was significantly reduced in SMTP-treated group compared with the vehicle group. Our results indicate that SMTP administration might induce not only fibrinolytic effectiveness, but also anti-oxidative injury after reperfusion due to transient cerebral ischemia.