Basic research of neurons specifically inducted from Oli2 positive progenitors for neural regeneration medicine
| Project/Area Number |
23791605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 再生医療 / Olig2 / 神経分化 / オリゴデンドロサイト / 運動ニューロン |
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| Research Abstract |
To elucidate function of bHLH transcriptional factor Olig2, gene expression pattern of fetal spinal cords between wild type mice and Olig2 knock-out mice was investigated with DNA subtraction method. Twelve genes were identified as candidates of downstream factors of Olig2 and expression patterns of theses genes were examined. Peroxiredoxin 1 was expressed specifically in the location of motoneurons, and was presumed to concern with differentiation for motoneurons.
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Report
(3 results)
Research Products
(7 results)
