Neurorestorative therapy for Stroke based on PrPcprotein

• Project/Area Number: 23791609
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Nagasaki University
• Principal Investigator: ISHIZAKA Shunsuke 長崎大学, 大学病院, 研究協力員 (10597363)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: stroke / PrPc / neuroprotection / 脳梗塞 / 再生医療 / プリオン / 正常プリオン蛋白 / 間葉系幹細胞 / 神経再生

Research Abstract

Our study clearly suggests that PrPc plays an important role against stroke. Although, the effect depends on the rodent strain, PrPc could provide neuro-protective or neuro-restrative effect and enhance functional recovery after stroke. In terms of the PrPc protein, total PrPc protein is preserved in stroke or vascular dementia and significantly reduced total PrPc protein in cerebrospinal fluid in Prion disease.

Research Products

• [Journal Article] Intra-arterial cell transplantation provides timing-dependent cell distribution and functional recovery after stroke. (2013)
  • Author(s): Ishizaka S, Horie N, Satoh K, Fukuda Y, Nishida N, Nagata I
  • Journal Title: Stroke. Volume: 44(3) Pages: 720-6
• [Journal Article] Intra-Arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke (2013)
  • Author(s): Shunsuke Ishizaka, Nobutaka Horie, Katsuya Satoh, Yuhtaka Fukuda, Noriyuki Nishida, Izumi Nagata
  • Journal Title: Stroke Volume: 44 Issue: 3 Pages: 720-726
  • DOI: 10.1161/strokeaha.112.677328
  • Peer Reviewed
• [Presentation] Intra-arterial cell transplantation provides timing-dependent cell distribution and functional recovery after stroke. (2013)
  • Author(s): Ishizaka S, Horie N, Satoh K, Nishida N, Nagata I
  • Organizer: International Stroke Conference, Oral presentation
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2013-02-07
• [Presentation] Timing of intra-arterial cell transplantation drastically affects the behavior of the transplanted cells and functional recovery after stroke. (2013)
  • Author(s): Ishizaka S, Horie N, Satoh K, Nishida N, Nagata I
  • Organizer: International Stroke Conference 2012
  • Place of Presentation: Hawaii USA
• [Presentation] ラット脳梗塞に対するヒト骨髄間葉系幹細胞の経動脈的移植 ～移植タイミングが治療メカニズムに及ぼす影響～ (2012)
  • Author(s): 石坂俊輔、堀江信貴、佐藤克也、西田教行、永田泉
  • Organizer: 第24回日本脳循環代謝学会
  • Place of Presentation: 広島
  • Year and Date: 2012-11-08
• [Presentation] 脳梗塞に対するヒト骨髄間質細胞の経動脈的移植の可能性 ～移植時期が細胞の挙動、治療効果に及ぼす影響～ (2012)
  • Author(s): 石坂俊輔、堀江信貴、佐藤克也、西田教行、永田泉
  • Organizer: 第37回日本脳卒中学会総会 シンポジウム
  • Place of Presentation: 脳卒中最先端の基礎研究から、福岡
  • Year and Date: 2012-04-26
• [Presentation] ラット脳梗塞モデルに対するヒト間葉系幹細胞の経動脈的移植～移植時期が細胞の挙動、治療効果に及ぼす影響について～ (2012)
  • Author(s): 石坂俊輔、堀江信貴、佐藤克也、西田教行、永田泉
  • Organizer: 第14回長崎障害者支援再生医療研究会、
  • Place of Presentation: ポンペ会館
  • Year and Date: 2012-03-13
• [Presentation] Timing of intra-arterial cell transplantation drastically affects the behavior of the transplanted cells and functional recovery after stroke. (2012)
  • Author(s): Ishizaka S, Horie N, Satoh K, Nishida N, Nagata I
  • Organizer: International Stroke Conference, Poster presentation
  • Place of Presentation: New Orleans, USA
• [Presentation] 脳梗塞に対する幹細胞動注療法における投与時期の相違 (2011)
  • Author(s): 石坂俊輔 堀江信貴 佐藤克也 西田教之 永田泉
  • Organizer: 第8回九州山口脳循環代謝フォーラム
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-22
• [Presentation] Timing of intra-arterial cell transplantation drastically affects the behavior of the transplanted cellsand functional recovery after stroke
  • Author(s): 石坂俊輔
  • Organizer: International stroke conference 2012
  • Place of Presentation: 米国