Neurorestorative therapy for Stroke based on PrPcprotein
| Project/Area Number |
23791609
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | stroke / PrPc / neuroprotection / 脳梗塞 / 再生医療 / プリオン / 正常プリオン蛋白 / 間葉系幹細胞 / 神経再生 |
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| Research Abstract |
Our study clearly suggests that PrPc plays an important role against stroke. Although, the effect depends on the rodent strain, PrPc could provide neuro-protective or neuro-restrative effect and enhance functional recovery after stroke. In terms of the PrPc protein, total PrPc protein is preserved in stroke or vascular dementia and significantly reduced total PrPc protein in cerebrospinal fluid in Prion disease.
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Report
(3 results)
Research Products
(10 results)
