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Stem cell transplantation for ischemic stroke focusing on timing and lesion specificity

Research Project

Project/Area Number 23791611
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionNagasaki University

Principal Investigator

HORIE Nobutaka  長崎大学, 大学病院, 助教 (70380912)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords脳梗塞 / 幹細胞 / 移植 / 再生医療 / mesenchymal stem cell / 動脈内投与
Research Abstract

Human mesenchymal stem cells were widely distributed both in the peri-infarct and core in D1, and dominantly in the peri-infarct in D4. Very few cells were observed on D7. At day 7 poststroke, microglia activation was significantly suppressed in both the peri-infarct and core in D1, and predominantly in the peri-infarct in D4. At day 21 poststroke, brain-derived neurotrophic factor was widely distributed throughout the peri-infarct in D1 and D4, along with many reactive astrocytes and considerable angiogenesis. Motor function improved earlier in D1 and later in D4, but no recovery was obtained in D7.
Our results indicate that intra-arterial cell transplantation provides timing-dependent cell distribution and poststroke functional recovery via a combination of neuroprotection, reactive astrocyte enhancement, and angiogenesis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (9 results)

  • [Journal Article] Intra-Arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke2013

    • Author(s)
      Shunsuke Ishizaka, Nobutaka Horie, Katsuya Satoh, Yuhtaka Fukuda, Noriyuki Nishida, Izumi Nagata
    • Journal Title

      Stroke

      Volume: 44 Issue: 3 Pages: 720-726

    • DOI

      10.1161/strokeaha.112.677328

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラット脳梗塞に対する血管内治療を用いた神経再生療法2013

    • Author(s)
      堀江信貴
    • Journal Title

      長崎県医師会報

      Volume: 806 Pages: 79-80

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Assessment of Carotid Plaque Stability Based on the Dynamic Enhancement Pattern in Plaque Components With Multidetector CT Angiography2012

    • Author(s)
      Horie Nobutaka, Morikawa Minoru, Ishizaka Shunsuke, Takeshita Tomonori, So Gohei, Hayashi Kentaro, Suyama Kazuhiko, Nagata Izumi
    • Journal Title

      Stroke

      Volume: 43 Issue: 2 Pages: 393-398

    • DOI

      10.1161/strokeaha.111.635953

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Direct arteriovenous fistula at the inferolateral trunk mimicking carotid cavernous fistula without involving the cavernous sinus: a case report.2012

    • Author(s)
      Horie N, Morikawa M, So G, Hayashi K, Suyama K, Nagata I.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 154 Issue: 3 Pages: 465-469

    • DOI

      10.1007/s00701-011-1226-8

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] New variant of persistent primitive olfactory artery associated with a ruptured aneurysm.2012

    • Author(s)
      Horie N, Morikawa M, Fukuda S, Hayashi K, Suyama K, Nagata I.
    • Journal Title

      J Neuorsurgery

      Volume: 117 Issue: 1 Pages: 26-28

    • DOI

      10.3171/2012.3.jns111932

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Selective coil embolization through flow-directed microcatheter for intracranial arteriovenous malformations2012

    • Author(s)
      Horie N, Hayashi K, Morikawa M, Nagata I.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 154(6) Issue: 6 Pages: 989-91

    • DOI

      10.1007/s00701-012-1287-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 脳梗塞に対する経動脈的幹細胞移植(血管内治療)は有用なdelivery routeとなりうるか -現状と将来性-2014

    • Author(s)
      堀江信貴、福田雄高、石坂俊輔、山口将、日宇健、佐藤克也、西田教行、永田泉、Gary Steinberg
    • Organizer
      Stroke 2014
    • Place of Presentation
      大阪国際会議場 (大阪市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた細胞移植療法の現状と課題2013

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田泉、ラファエル・グズマン、トニア・ブリス、ゲイリー・スタインバーグ
    • Organizer
      Stroke 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Strokeに対するヒト神経幹細胞移植後の内在性修復機構活性化2013

    • Author(s)
      堀江信貴、日宇健、永田泉、Tonya Bliss、Gary K. Steinberg
    • Organizer
      Stroke 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた幹細胞移植の可能性2012

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田泉、Raphael Guzman, Tonya Bliss, Gary K Steinberg
    • Organizer
      【シンポジウム"脳血管内治療のリサーチワーク"】第28回日本脳神経血管内治療学会総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた幹細胞移植の可能性―経静脈的投与との相違―Endovascular stem cell transplantation for Stroke- difference between IV and IA-2012

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田泉、Raphael Guzman, Tonya Bliss, Gary K Steinberg
    • Organizer
      【シンポジウム"幹細胞と再生医療"】第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Endovascular stem cell transplantation is promising for the post-stroke functional recovery2012

    • Author(s)
      Nobutaka Horie, Shunsuke Ishizaka, Katsuya Satoh, Noriyuki Nishida, Izumi Nagata
    • Organizer
      10th meeting of Asian Australasian Federation of Interventional and Therapeutic Neuroradiology
    • Place of Presentation
      Nagoya
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた幹細胞移植の可能性2012

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田 泉、Raphael Guzman, Tonya Bliss, Gary K Steinberg
    • Organizer
      第71回 日本脳神経外科学会総会 シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳梗塞に対する脳血管内治療を用いた幹細胞移植の可能性2012

    • Author(s)
      堀江信貴、石坂俊輔、福田雄高、佐藤克也、西田教行、永田 泉、Raphael Guzman, Tonya Bliss, Gary K Steinberg
    • Organizer
      第28回日本脳神経血管内治療学会総会 シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] Timing Of Intra-arterial Cell Transplantation Drastically Affects The Behavior Of The Transplanted Cells And Functional Recovery After Stroke2012

    • Author(s)
      Ishizaka Shunsuke, Nobutaka Horie
    • Organizer
      International Stroke Conference 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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