Activities of the neural stem cells after cerebral ischemia
| Project/Area Number |
23791612
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 内因性神経幹細胞 / 虚血後応答 / 中枢神経 / 虚血細胞死 / 全脳虚血モデル / 内在性神経幹細胞 |
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| Research Abstract |
To assess endogenous neural stem cell activation after ischemia, we have focused on hippocampal pyramidal cells using global ischemia model. The delayed neuronal death was highly observed by permanent bilateral vertebral artery occlusion in addition to transient bilateral carotid artery occlusion. This model allows monitoring of regeneration, however, we could not confirm obvious regeneration after treatment. Further study is necessary to confirm whether this negative finding is reproducible phenomenon.
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss2013
Author(s)
Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, Ichimura k
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Journal Title
Acta Neuropathol
Volume: (in press)
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Peer Reviewed
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[Presentation] グリオーマ手術における治療成績向上を目的とした多角的アプローチ2011
Author(s)
立石健祐,佐藤充,山田幸子,中村大志,上野龍,園田真樹,善積哲也,高瀬創,日暮雅一,村田英俊,横山高玲,菅野洋,川原信隆
Organizer
第5回神奈川脳神経外科集談会
Place of Presentation
崎陽軒(神奈川県)
Year and Date
2011-02-19
Related Report
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