Neural and vascular specific microRNA as a novel approach for the treatment of injured spinal cord
Project/Area Number |
23791646
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
|
Research Institution | Hiroshima University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 再生医療 / 再生医学 / 神経科学 |
Research Abstract |
Administration of microRNA-210 to the spinal cord injury models enhanced angiogenesis, astrogliosis, axon growth and functional recovery following injury. Administration of microRNA-210 downregulated the expression of PTP1B, P-Erk1/2, EFNA3 and promoted Wnt signaling. These might participate in the mechanisms of spinal cord regeneration through the promotion of angiogenesis.
|
Report
(3 results)
Research Products
(46 results)