Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation

Research Project

Project/Area Number	23791679
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	Nagoya University
Principal Investigator	TAKAHASHI Nobunori 名古屋大学, 医学部附属病院, 病院助教 (20570196)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	変形性関節症 / ヒアルロン酸 / CD44 / 断片化 / Lipid Raft / Statin製剤 / CD44の断片化抑制
Research Abstract	We demonstrated that simvastatin effectively inhibited the IL-1/OSM induced CD44 cleavage. This inhibitory effect would mainly depend on the suppressive cholesterol production, the major component of lipid raft. However, our current results also suggest that the Ras and Rac/Rho pathway were included in the mechanism of the suppressive CD44 cleavage. The interactional expression of membrane type MMPs (MT-MMP, ADAM10 and 17) were included in this mechanism.

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(3 results)