Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation
Project/Area Number |
23791679
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
|
Research Institution | Nagoya University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 変形性関節症 / ヒアルロン酸 / CD44 / 断片化 / Lipid Raft / Statin製剤 / CD44の断片化抑制 |
Research Abstract |
We demonstrated that simvastatin effectively inhibited the IL-1/OSM induced CD44 cleavage. This inhibitory effect would mainly depend on the suppressive cholesterol production, the major component of lipid raft. However, our current results also suggest that the Ras and Rac/Rho pathway were included in the mechanism of the suppressive CD44 cleavage. The interactional expression of membrane type MMPs (MT-MMP, ADAM10 and 17) were included in this mechanism.
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Report
(3 results)
Research Products
(4 results)