Effects of GABA receptors on lung protection in patients with mechanical ventilation

• Project/Area Number: 23791700
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gifu University
• Principal Investigator: SUGIYAMA Yoko 岐阜大学, 医学(系)研究科(研究院), 助教 (70444255)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 気道上皮 / ムチン / 麻酔薬 / GABA受容体 / 喫煙 / シグナル伝達 / 気道免疫 / 人工呼吸 / 肺保護 / 鎮静薬

Research Abstract

Propofol but not sevoflurane enhanced cigarette smoke extract (CSE)-induced MUC5AC production in human airway epithelial cells. Propofol increased p44/42 MAP kinase phosphorylation and PD98059 abolished the enhancement of MUC5AC production induced by propofol. GABAA antagonists failed to block the effect of propofol.
These results suggest that propofol enhanced MUC5AC production induced by CSE in p44/42 MAP kinase dependent and GABAA receptor independent manner. Propofol may have the potential to amplify overproduction of airway mucus in smokers. Some anesthertics may affect respiratory condition in smokers or patients with chronic pulmonary diseases during mechanical ventilation.

Research Products

• [Journal Article] Anesthetic management for a patient with very-long-chain acyl-coenzyme A dehydrogenase deficiency (2012)
  • Author(s): Iwata K, Tanabe K, Sugiyama Y, Tanaka M, Takenaka M, Iida H
  • Journal Title: J Anesth Volume: 26 Pages: 957-958
  • Peer Reviewed
• [Presentation] Propofol modulates muchin production in H292 airway epithelial cells after exposure to cigarette smoke extract (2013)
  • Author(s): Yoko Sugiyama, Kumiko Tanabe, Hiroki Iida
  • Organizer: American Soceity of Anesthesiologists 2013 Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2013-10-12
• [Presentation] Propofol modulates mucin production in H292 airway epithelial cells after exposure to cigarette smoke extract (2013)
  • Author(s): Yoko Sugiyama, Kumiko Tanabe, Hiroki Iida
  • Organizer: The annual meeting of the American society of Anesthesiologist
  • Place of Presentation: サンフランシスコ、米国
• [Presentation] Effects of Intravenous Anesthetics and Sedatives on Mucin Production in Human Airway Epithelial Cells (2011)
  • Author(s): Yoko Sugiyama, Kumiko Tanabe, Hiroki Iida
  • Organizer: Annual meeting of American Society of Anesthesiologist
  • Place of Presentation: Chicago, USA
• [Book] 脊髄くも膜下硬膜外併用麻酔と脊髄くも膜下鎮痛単独:麻酔科医のための周術期疼痛管理 (2014)
  • Author(s): 杉山陽子、飯田宏樹、川真田樹人編
  • Publisher: 中山書店(東京)