Effect of preoperative carbohydrate loading on intestine mucosa and insulin resistance

• Project/Area Number: 23791708
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kochi University
• Principal Investigator: YATABE Tomoaki 高知大学, 教育研究部医療学系, 助教 (60437720)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 周術期管理 / 術前炭水化物負荷 / インスリン抵抗性 / 腸管機能 / 経口摂取

Research Abstract

Anesthesiologists and surgeon practice preoperative carbohydrate loading because it improves a perioperative management. In this basic study, we revealed that preoperative carbohydrate loading might protect the intestine mucosa. Furthermore, carbohydrate loading improved the insulin resistance in the volunteer study. This knowledge might contribute to improvement of a perioperative patients’ outcome.

Research Products

• [Journal Article] Oral carbohydrate loading with 18% carbohydrate beverage alleviates insulin resistance (2013)
  • Author(s): Tamura T, Yatabe T, Kitagawa H, Yamashita K, Hanazaki K, Yokoyama M
  • Journal Title: Asia Pac J Clin Nutr Volume: 22 Pages: 48-53
  • NAID: 10031196405
  • Peer Reviewed
• [Journal Article] Oral carbohydrate loading with 18% carbohydrate beverage alleviates insulin resistance. (2013)
  • Author(s): Tamura T, Yatabe T, Kitagawa H, Yamashita K, Hanazaki K, Yokoyama M.
  • Journal Title: Asia Pac J Clin Nutr. Volume: 22 Pages: 48-53
  • NAID: 10031196405
  • Peer Reviewed
• [Presentation] 術前経口補水療法が腸管粘膜に与える影響に関する基礎的研究 (2013)
  • Author(s): 矢田部智昭,横山正尚
  • Organizer: 第28回日本静脈経腸栄養学会学術集会
  • Place of Presentation: 金沢
• [Presentation] 術前経口補水療法が腸管粘膜に与える影響に関する基礎的研究 (2013)
  • Author(s): 矢田部智昭，横山正尚
  • Organizer: 第28回日本静脈経腸栄養学会学術集会
  • Place of Presentation: 金沢都ホテル（石川）
• [Presentation] 18%炭水化物含有飲料によるインスリン抵抗性改善効果に関する検討 (2012)
  • Author(s): 山中大樹,矢田部智昭,山下幸一,横山正尚
  • Organizer: 日本臨床麻酔学会第32回大会
  • Place of Presentation: 郡山
• [Presentation] 飲んで治す!アルジネードウォーターが変えるインスリン抵抗性 (2012)
  • Author(s): 矢田部智昭
  • Organizer: 日本臨床麻酔学会第32回大会
  • Place of Presentation: 郡山
• [Presentation] Oral carbohydrate loading with 18% carbohydrate beverage alleviates insulin resistance (2012)
  • Author(s): T.Tamura, T.Yatabe, K.Yamashita, M.Yokoyama
  • Organizer: ESPEN2012
  • Place of Presentation: Barcelona Spain
• [Presentation] Oral carbohydrate loading with 18% carbohydrate beverage alleviates insulin resistance. (2012)
  • Author(s): T.Tamura, T.Yatabe, K.Yamashita, M.Yokoyama.
  • Organizer: ESPEN2012
  • Place of Presentation: International Convention Centre of Barcelona（スペイン）
• [Presentation] 飲んで治す！アルジネードウォーターが変えるインスリン抵抗性 (2012)
  • Author(s): 矢田部智昭
  • Organizer: 日本臨床麻酔学会第32回大会
  • Place of Presentation: ビッグパレットふくしま（福島）
  • Invited
• [Presentation] 18%炭水化物含有飲料によるインスリン抵抗性改善効果に関する検討 (2012)
  • Author(s): 山中大樹，矢田部智昭，山下幸一，横山正尚
  • Organizer: 日本臨床麻酔学会第32回大会
  • Place of Presentation: ビッグパレットふくしま（福島）