The secretions from neuroendocrine cell promotes gelsolin-mediated motility of prostate cancer

• Project/Area Number: 23791765
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Sapporo Medical University
• Principal Investigator: HASHIMOTO Kohei 札幌医科大学, 医学部, 訪問研究員 (40404678)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺癌 / 神経内分泌細胞 / 去勢抵抗性 / ゲルゾリン、進展 / ゲルゾリン / 進展 / 前立腺神経内分泌細胞 / 神経内分泌因子 / ゲルゾリンタンパク質 / 浸潤能分析 / RNA干渉法

Research Abstract

The purpose of this study was to investigate the interactions between NE cells and LNCaP cells and the involvement of gelsolin in contributing to invasive potential of LNCaP cells. The present study indicates that neuroendocrine (NE) cells and neurotensin induced gelsolin-mediated motility of LNCaP cells through NTSR1 activation involving phospholipase C- intracellular calcium ion mobilization.

Research Products

• [Presentation] 前立腺神経内分泌細胞を介した前立腺癌の進展機構 (2011)
  • Author(s): 橋本浩平
  • Organizer: 第383回日本泌尿器科学会北海道地方会
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-18
• [Presentation] Neuroendocrine cell-cancer interaction induced by EGF promotes gelsolinmediated invasion of prostate cancer cells (2011)
  • Author(s): Hashimoto K, Masumori N, Tanaka T, Kitamura H, Tsukamoto T
  • Organizer: American Urological Association annual meeting 2011
  • Place of Presentation: USA, Washington DC
  • Year and Date: 2011-05-16
• [Presentation] 前立腺神経内分泌細胞による前立腺癌の gelsolin 1 を介する進展機構の解明 (2011)
  • Author(s): 橋本浩平、舛森直哉、田中俊明、北村 寛、塚本泰司
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-22
• [Presentation] 前立腺神経内分泌細胞による前立腺癌のゲルゾリンを介する進展機構の解明 (2011)
  • Author(s): 橋本浩平、舛森直哉、田中俊明、北村 寛、塚本泰司
  • Organizer: 第20回泌尿器科分子・細胞研究会
  • Place of Presentation: 津市
  • Year and Date: 2011-03-12
• [Presentation] Neuroendocrine cell-cancer interaction induced by EGF promotes gelsolin-mediated invasion of prostate cancer cells (2011)
  • Author(s): Kohei Hashimoto
  • Organizer: American Urological Association Annual Meeting 2011
  • Place of Presentation: ワシントンD.C (USA)
• [Presentation] 前立腺神経内分泌細胞による前立腺癌のgelsolinを介する進展機構の解明 (2011)
  • Author(s): 橋本浩平
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市