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Identification of novel urine biomarkers using molecules which was Specifically expressed in bladder cancer

Research Project

Project/Area Number 23791782
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionIwate Medical University

Principal Investigator

TAKATA Ryo  岩手医科大学, 医学部, 講師 (00438467)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords膀胱癌 / バイオマーカー / 遺伝子 / 尿
Research Abstract

As new diagnostic tools of bladder cancer, we attempted to establish novel urine biomarker for the bladder cancer. Although we analyzed gene expression levels of MPHOSPH1 and DEPDC1, contamination of white blood cells affected the results. Therefore we corrected contamination level using expression levels of CD13 and CD31. As a results, when we use CD31 expression as correction factor, Expression levels of MPHOSPH1 and DEPDC1 of bladder cancer patients were higher than that of normal controls. Protein expression level showed similar result.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (11 results)

  • [Journal Article] Neoadjuvant gemcitabine plus carboplatin for locally advanced bladder cancer2013

    • Author(s)
      Iwasaki K, Obara W, Kato Y, Takata R, et al
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(2) Pages: 193-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of four loci on serum tamsulosin hydrochloride concentration2013

    • Author(s)
      Takata R, Matsuda K, Sugimura J, et al
    • Journal Title

      J Hum Genet

      Volume: 58(1) Pages: 21-6

    • NAID

      10031145896

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer peptide vaccine therapy developed from oncoantigens identified through genome-wide expression profile analysis for bladder cancer2013

    • Author(s)
      Obara W, Ohsawa R, Kanehira M, Takata R, et al
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42(7) Pages: 591-600

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of four loci on serum tamsulosin hydrochloride concentration2013

    • Author(s)
      Takata Ryo, Matsuda Koichi, Sugimura Jun, Obara Wataru, Fujioka Tomoaki, Okihara Koji, Takaha Natsuki, Miki Tsuneharu, Ashida Shingo, Inoue Keiji, Tanikawa Chizu, Shuin Taro, Sasaki Shoichi, Kojima Yoshiyuki, Kohri Kenjiro, Kubo Michiaki, Yamaguchi Masao, Ohnishi Yozo, Nakamura Yusuke
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Issue: 1 Pages: 21-26

    • DOI

      10.1038/jhg.2012.126

    • NAID

      10031145896

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese2012

    • Author(s)
      Akamatsu S, Takahashi A, Takata R, et al
    • Journal Title

      PLoS One

      Volume: 7(10)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012

    • Author(s)
      Akamatsu S, Takata R, Haiman CA, et al
    • Journal Title

      Nat Genet

      Volume: 44(4) Pages: 426-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility i n Japanese2012

    • Author(s)
      Nguyen HH, Takata R , Akamatsu S, et al
    • Journal Title

      Hum Mol Genet

      Volume: 21(9) Pages: 2076-85

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostate cancer genomics, biology, and risk assessment through genome-wide association studies2012

    • Author(s)
      Nakagawa H, Akamatsu S, Takata R, et al
    • Journal Title

      Cancer Sci

      Volume: 103(4)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese.2012

    • Author(s)
      赤松秀輔
    • Journal Title

      Plos One

      Volume: 7 Issue: 10 Pages: 46454-46454

    • DOI

      10.1371/journal.pone.0046454

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer2012

    • Author(s)
      Ha Nguyen H, 他
    • Journal Title

      Human Molecular Genetics

      Volume: 21 Issue: 9 Pages: 2076-2085

    • DOI

      10.1093/hmg/dds025

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012

    • Author(s)
      赤松秀輔, 他
    • Journal Title

      Nature Genetics

      Volume: 44 Issue: 4 Pages: 426-429

    • DOI

      10.1038/ng.1104

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 前立腺癌発症関連領域5p15に局在するIRX4はビタミンDレセプターに結合し前立腺癌の増殖を抑制する2013

    • Author(s)
      高田亮、Hai Ha Nguyen、赤松秀輔、他
    • Organizer
      第22回泌尿器科分子・細胞研究会
    • Place of Presentation
      高知
    • Year and Date
      2013-03-09
    • Related Report
      2012 Final Research Report
  • [Presentation] IRX4 at 5p15 supress prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptilbility2012

    • Author(s)
      Ryo Takata, Hai Ha Nguyen, Shusuke Akamatsu, et al
    • Organizer
      15th international congress on hormonal steroids and hormones & cancer
    • Place of Presentation
      金沢
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of genetic polymorphism associated with response to docetaxel in prostate cancer patients2012

    • Author(s)
      Ryo Takata, Wataru Obara, Hidewaki Nakagawa, et al
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Risk estimation model with multiple common genetic variants for Japanese prostate cancer2012

    • Author(s)
      Ryo Takata, Shusuke Akamatsu, Hidewaki Nakagawa, et al
    • Organizer
      AUA annual meetings
    • Place of Presentation
      アトランタ
    • Year and Date
      2012-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本における全ゲノム関連解析(GWAS)の現状と今後-前立腺癌-2012

    • Author(s)
      高田亮、赤松秀輔、中川英刀、他
    • Organizer
      第100回日本泌尿器科総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本における全ゲノム解析(GWAS)の現状と今後2012

    • Author(s)
      高田 亮
    • Organizer
      日本泌尿器科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of genetic polymorphism associated with response to decetaxel in prostate cancer patients.2012

    • Author(s)
      高田 亮
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Risk estimation model with multiple common genetic variants for Japanese prostate cancer2011

    • Author(s)
      Ryo Takata, Shusuke Akamatsu, Hidewaki Nakagawa, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Genome-wide association study identifies multiple new susceptibility loci for prostate cancer in Japanese population2011

    • Author(s)
      Ryo Takata, Shusuke Akamatsu, Hideaki Nakagawa, et al
    • Organizer
      AUA annual meeting
    • Place of Presentation
      ワシントン
    • Year and Date
      2011-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人の前立腺癌に関連する遺伝子多型の同定とその臨床的意義2011

    • Author(s)
      高田亮、赤松秀輔、中川英刀、他
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Risk estimation model with multiple common genetic variants for Japanese prostate cancer.2011

    • Author(s)
      高田亮、他
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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