Identification of novel urine biomarkers using molecules which was Specifically expressed in bladder cancer

• Project/Area Number: 23791782
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Iwate Medical University
• Principal Investigator: TAKATA Ryo 岩手医科大学, 医学部, 講師 (00438467)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 膀胱癌 / バイオマーカー / 遺伝子 / 尿

Research Abstract

As new diagnostic tools of bladder cancer, we attempted to establish novel urine biomarker for the bladder cancer. Although we analyzed gene expression levels of MPHOSPH1 and DEPDC1, contamination of white blood cells affected the results. Therefore we corrected contamination level using expression levels of CD13 and CD31. As a results, when we use CD31 expression as correction factor, Expression levels of MPHOSPH1 and DEPDC1 of bladder cancer patients were higher than that of normal controls. Protein expression level showed similar result.

Research Products

• [Journal Article] Neoadjuvant gemcitabine plus carboplatin for locally advanced bladder cancer (2013)
  • Author(s): Iwasaki K, Obara W, Kato Y, Takata R, et al
  • Journal Title: Jpn J Clin Oncol Volume: 43(2) Pages: 193-9
  • Peer Reviewed
• [Journal Article] Impact of four loci on serum tamsulosin hydrochloride concentration (2013)
  • Author(s): Takata R, Matsuda K, Sugimura J, et al
  • Journal Title: J Hum Genet Volume: 58(1) Pages: 21-6
  • NAID: 10031145896
  • Peer Reviewed
• [Journal Article] Cancer peptide vaccine therapy developed from oncoantigens identified through genome-wide expression profile analysis for bladder cancer (2013)
  • Author(s): Obara W, Ohsawa R, Kanehira M, Takata R, et al
  • Journal Title: Jpn J Clin Oncol Volume: 42(7) Pages: 591-600
  • Peer Reviewed
• [Journal Article] Impact of four loci on serum tamsulosin hydrochloride concentration (2013)
  • Author(s): Takata Ryo, Matsuda Koichi, Sugimura Jun, Obara Wataru, Fujioka Tomoaki, Okihara Koji, Takaha Natsuki, Miki Tsuneharu, Ashida Shingo, Inoue Keiji, Tanikawa Chizu, Shuin Taro, Sasaki Shoichi, Kojima Yoshiyuki, Kohri Kenjiro, Kubo Michiaki, Yamaguchi Masao, Ohnishi Yozo, Nakamura Yusuke
  • Journal Title: Journal of Human Genetics Volume: 58 Issue: 1 Pages: 21-26
  • DOI: 10.1038/jhg.2012.126
  • NAID: 10031145896
  • Peer Reviewed
• [Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese (2012)
  • Author(s): Akamatsu S, Takahashi A, Takata R, et al
  • Journal Title: PLoS One Volume: 7(10)
  • Peer Reviewed
• [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese (2012)
  • Author(s): Akamatsu S, Takata R, Haiman CA, et al
  • Journal Title: Nat Genet Volume: 44(4) Pages: 426-9
  • Peer Reviewed
• [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility i n Japanese (2012)
  • Author(s): Nguyen HH, Takata R , Akamatsu S, et al
  • Journal Title: Hum Mol Genet Volume: 21(9) Pages: 2076-85
  • Peer Reviewed
• [Journal Article] Prostate cancer genomics, biology, and risk assessment through genome-wide association studies (2012)
  • Author(s): Nakagawa H, Akamatsu S, Takata R, et al
  • Journal Title: Cancer Sci Volume: 103(4)
  • Peer Reviewed
• [Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese. (2012)
  • Author(s): 赤松秀輔
  • Journal Title: Plos One Volume: 7 Issue: 10 Pages: 46454-46454
  • DOI: 10.1371/journal.pone.0046454
  • Peer Reviewed
• [Journal Article] IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer (2012)
  • Author(s): Ha Nguyen H, 他
  • Journal Title: Human Molecular Genetics Volume: 21 Issue: 9 Pages: 2076-2085
  • DOI: 10.1093/hmg/dds025
  • Peer Reviewed
• [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese (2012)
  • Author(s): 赤松秀輔, 他
  • Journal Title: Nature Genetics Volume: 44 Issue: 4 Pages: 426-429
  • DOI: 10.1038/ng.1104
  • Peer Reviewed
• [Presentation] 前立腺癌発症関連領域5p15に局在するIRX4はビタミンDレセプターに結合し前立腺癌の増殖を抑制する (2013)
  • Author(s): 高田亮、Hai Ha Nguyen、赤松秀輔、他
  • Organizer: 第22回泌尿器科分子・細胞研究会
  • Place of Presentation: 高知
  • Year and Date: 2013-03-09
• [Presentation] IRX4 at 5p15 supress prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptilbility (2012)
  • Author(s): Ryo Takata, Hai Ha Nguyen, Shusuke Akamatsu, et al
  • Organizer: 15th international congress on hormonal steroids and hormones & cancer
  • Place of Presentation: 金沢
  • Year and Date: 2012-11-16
• [Presentation] Identification of genetic polymorphism associated with response to docetaxel in prostate cancer patients (2012)
  • Author(s): Ryo Takata, Wataru Obara, Hidewaki Nakagawa, et al
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Risk estimation model with multiple common genetic variants for Japanese prostate cancer (2012)
  • Author(s): Ryo Takata, Shusuke Akamatsu, Hidewaki Nakagawa, et al
  • Organizer: AUA annual meetings
  • Place of Presentation: アトランタ
  • Year and Date: 2012-05-20
• [Presentation] 日本における全ゲノム関連解析(GWAS)の現状と今後-前立腺癌- (2012)
  • Author(s): 高田亮、赤松秀輔、中川英刀、他
  • Organizer: 第100回日本泌尿器科総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-24
• [Presentation] 日本における全ゲノム解析（GWAS）の現状と今後 (2012)
  • Author(s): 高田 亮
  • Organizer: 日本泌尿器科学会
  • Place of Presentation: 横浜
• [Presentation] Identification of genetic polymorphism associated with response to decetaxel in prostate cancer patients. (2012)
  • Author(s): 高田 亮
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌
• [Presentation] Risk estimation model with multiple common genetic variants for Japanese prostate cancer (2011)
  • Author(s): Ryo Takata, Shusuke Akamatsu, Hidewaki Nakagawa, et al
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Genome-wide association study identifies multiple new susceptibility loci for prostate cancer in Japanese population (2011)
  • Author(s): Ryo Takata, Shusuke Akamatsu, Hideaki Nakagawa, et al
  • Organizer: AUA annual meeting
  • Place of Presentation: ワシントン
  • Year and Date: 2011-05-15
• [Presentation] 日本人の前立腺癌に関連する遺伝子多型の同定とその臨床的意義 (2011)
  • Author(s): 高田亮、赤松秀輔、中川英刀、他
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-22
• [Presentation] Risk estimation model with multiple common genetic variants for Japanese prostate cancer. (2011)
  • Author(s): 高田亮、他
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋