The molecular mechanism of chemokines and tumor associated macrophages in the progression of prostate cancer

• Project/Area Number: 23791785
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: SHIROTAKE Suguru 慶應義塾大学, 医学部, 助教 (10528805)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 泌尿器癌 / 微小環境 / 前立腺癌 / マクロファージ / MCP-1

Research Abstract

Our study clearly demonstrated that both high MCP-1 expression and high tumor associated macrophage infiltration in prostate cancer specimens correlatedwith a high PSA recurrence rate, and that angiotensin II type 1 receptor blockade inhibitedMCP-1 expres

Research Products

• [Journal Article] The predictive value of C-reactive protein for prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy: a multi-institutional study (2012)
  • Author(s): Tanaka N, Kikuchi E, Shirotake S, Kanao K, Matsumoto K, Kobayashi H et al
  • Journal Title: Eur Urol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1receptor in prostate cancer (2012)
  • Author(s): Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M
  • Journal Title: Am J Pathol. Volume: 180(3) Issue: 3 Pages: 1008-16
  • DOI: 10.1016/j.ajpath.2011.11.027
  • Peer Reviewed
• [Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer (2012)
  • Author(s): Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M.
  • Journal Title: American Journal of Pathology Volume: 180 Pages: 1008-16
  • Peer Reviewed
• [Presentation] 前立腺癌におけるアンギオテンシンII 1型受容体を介したMCP-1の発現制御に関する検討 (2013)
  • Author(s): 城武卓、宮嶋哲、小坂威雄、菊地栄次、大家基嗣
  • Organizer: 第101回日本泌尿器学会総会
  • Place of Presentation: 北海道
  • Year and Date: 2013-04-26
• [Presentation] 前立腺癌におけるMCP-1の発現制御に関する検討 (2012)
  • Author(s): 宮嶋哲、城武卓、小坂威雄、菊地栄次、大家基嗣
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-06-28
• [Presentation] The regulation of MCP-1 expression through angiotensin II type 1 receptor in castration-resistantprostate cancer (2012)
  • Author(s): Suguru Shirotake, Akira Miyajima, Takeo Kosaka, Nobuyuki Tanaka, Eiji Kikuchi, Mototsugu Oya
  • Organizer: American urological association annual meeting 2012
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2012-05-21
• [Presentation] The regulation of MCP-1 expression through angiotensin II type 1 receptor in castration-resistant prostate cancer (2012)
  • Author(s): Suguru Shirotake
  • Organizer: American urological association
  • Place of Presentation: アトランタ
• [Presentation] 前立腺癌におけるアンギオテンシンII 1型受容体を介したMCP-1の発現制御に関する検討 (2012)
  • Author(s): 城武卓
  • Organizer: 関東ホルモンと癌研究会
  • Place of Presentation: 東京大学
• [Presentation] 前立腺癌におけるMCP-1の発現制御に関する検討
  • Author(s): 宮嶋哲
  • Organizer: 日本がん分子標的治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] 前立腺癌におけるアンギオテンシンII 1型受容体を介したMCP-1の発現制御に関する検討
  • Author(s): 城武卓
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 北海道
• [Remarks]
  • URL: http://www.keio-urology.jp/