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Development of anti cancer drug targeting longevity related gene -SIRT1 using nanotechnology.

Research Project

Project/Area Number 23791811
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

SONE Kembun  東京大学, 医学部付属病院, 助教 (90598872)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsSIRT1 / DBC-1 / アポトーシス / カスパーゼ / E-cadherin / 子宮内膜 / 子宮体癌 / 細胞接着能 / レズベラトロール / sirtinol / 子宮体癌細胞株
Research Abstract

We elucidated function analysis of SIRT1 and DBC-1 in apoptosis. And We analyzed the function of SIRT1 in endometrium.
We confirmed that DBC-1 is targeted for cleavage by caspase-7 during the process of apoptosis. In addition, Endgeneous SIRT1 and DBC-1 localize to the nucleus in healthy cells and to the cytoplasm during apoptosis, and possibly induce apoptosis signal.
In endometrium,SIRT1 plays an important role in regulating E-cadherin and induce cell-attachment.and There is possiblility that SIRT1 is related to human cancinogene- sis in endometrium and capacity of an embrio to attach.

Report

(3 results)
  • 2012 Final Research Report ( PDF )
  • 2011 Research-status Report   Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (9 results)

  • [Journal Article] Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines2013

    • Author(s)
      Miyamoto Y, Nakagawa S, Wada-Hiraike O, Seiki T, Tanikawa M, Hiraike H, Sone K, Nagasaka K, Oda K, Kawana K, Nakagawa K, Fujii T, Yano T, Kozuma S, Taketani Y.
    • Journal Title

      Oncol Rep.

      Volume: 29 Issue: 1 Pages: 51

    • DOI

      10.3892/or.2012.2072

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] equential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines2012

    • Author(s)
      Miyamoto Y, Nakagawa S, Wada-Hiraike O, Seiki T, Tanikawa M, Hiraike H, Sone K, Nagasaka K, Oda K, Kawana K, Nakagawa K, Fujii T, Yano T, Kozuma S, Taketani Y.
    • Journal Title

      Oncology Reports

      Volume: 29 Pages: 51-57

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression2012

    • Author(s)
      Shirane A, Wada-Hiraike O, Tanikawa M, Seiki T, Hiraike H, Miyamoto Y, Sone K, Hirano M, Oishi H, Oda K, Kawana K, Nakagawa S, Osuga Y, Fujii T, Yano T, Kozuma S, Taketani Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 424 Issue: 3 Pages: 604

    • DOI

      10.1016/j.bbrc.2012.06.160

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas2012

    • Author(s)
      Shoji K, Oda K, Nakagawa S,-Hiraike O, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e37431-e37431

    • DOI

      10.1371/journal.pone.0037431

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol promotes expression on SIRT1 And StAR in rad ovarian granulosa cells2012

    • Author(s)
      Morita Y,Wada-Hiraike O,Yano T,Shirane A,Hirano M,Hiraike H,Koyama S,Oisihi H, Yoshino O,Miyamoto Y,Sone K,Oda K, Nakagawa S,Tsutsui k,Taketani Y
    • Journal Title

      an Implicative role of SIRT1 in the ovary Reproductive Biology and endocrinology

      Volume: 10 Pages: 14-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: An implicative role of SIRT1 in the ovary2012

    • Author(s)
      Y.Morita, K.Tsutsui, et al
    • Journal Title

      Reprod.Biol.Endocrinbl.

      Volume: 10 Issue: 1 Pages: 14-24

    • DOI

      10.1186/1477-7827-10-14

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multifunctional transpription factor TF II?1 is an activator of BRACA1 function2011

    • Author(s)
      Tanikawa M,Wada-Hiraike O,Nakagawa S, Shirane A,Hiraike H,Koyama S,Miyamoto Y Sone K,Tsuruga T,Nagasaka K,Matsumoto Y, Ikeda Y,Shoji K,Oda K,Fukuhara H,Nakagawa K,Kato S,Yano T,Taketani Y
    • Journal Title

      British journal of cancer

      Volume: 104 Pages: 1349-1355

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function2011

    • Author(s)
      Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, et al
    • Journal Title

      Br J Cancer

      Volume: 104 Issue: 8 Pages: 1349

    • DOI

      10.1038/bjc.2011.75

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 子宮体癌リンパ節転移陽性(臨床進行期IIIc)例における予後因子の検討2012

    • Author(s)
      園田正樹、織田克利,有本貴英,武家尾舞子,曾根献文,森繭代,松本陽子,川名敬,中川俊介,矢野哲,上妻志郎,武谷雄二
    • Organizer
      日本婦人科腫瘍学会
    • Place of Presentation
      新高輪プリンスホテル
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 当科での子宮内膜異型増殖症、高分化子宮体癌に対するMPA療法を用いた妊孕性温存治療に関する検討2012

    • Author(s)
      宮本雄一郎、佐藤英貴、三浦紫保、長阪一憲、曾根献文, 松本陽子, 有本貴英, 織田克利, 川名敬, 矢野哲, 上妻志郎, 武谷雄二
    • Organizer
      日本婦人科腫瘍学会
    • Place of Presentation
      新高輪プリンスホテル
    • Year and Date
      2012-07-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗老化分子SIRT1活性化物2012

    • Author(s)
      白根晃他
    • Organizer
      日本内分泌学会
    • Place of Presentation
      名古
    • Year and Date
      2012-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗老化分子SIRT1活性化物質レスベラトロールは細胞接着分子E-cadherinの発現を制御し胚の子宮内膜接着能を向上させる2012

    • Author(s)
      白根晃, 他
    • Organizer
      日本内分泌学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-04-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再発卵巣癌に対するsalvage chemotherapy2011

    • Author(s)
      曾根献文、松本陽子、森繭代、有本貴英、
    • Organizer
      日本癌治療学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 当科での子宮内膜異型増殖症、高分化子宮体癌に対するMPA療法を用いた妊孕性温存治療に関する検討胚細胞性腫瘍に対するBEP療法の有害事象と妊孕性に関する検討2011

    • Author(s)
      宮本雄一郎、佐藤英貴,三浦紫保,長阪一憲,曾根献文,松本陽子,有本貴英,織田克利,川名敬,矢野哲,上妻志郎,武谷雄二
    • Organizer
      日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2011-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 胚細胞性腫瘍に対するBEP療法の有害事象2011

    • Author(s)
      曾根献文、有本貴英、川名敬、塚崎雄大、
    • Organizer
      日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2011-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 胚細胞性腫瘍に対するBEP療法の有害事象と妊孕性に関する検討2011

    • Author(s)
      曾根献文、有本貴英、川名敬、塚崎雄大、松本陽子、土谷聡、西田晴香、織田克利、中川俊介、上妻志郎、武谷雄二
    • Organizer
      日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2011 Research-status Report
  • [Presentation] 再発卵巣癌に対するsalvage chemotherapy としてのweekly CPT-11療法の有用性の検討2011

    • Author(s)
      曾根献文、松本陽子、森繭代、有本貴英、織田克利、川名敬、中川俊介、上妻志郎、武谷雄二
    • Organizer
      日本癌治療学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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