| Project/Area Number |
23791815
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OISHI Hajime 東京大学, 医学部附属病院, 助教 (40401088)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生殖医学 / FOXL2 / 卵胞発育 / ステロイド合成 / 性ステロイド合成 / 卵巣顆粒膜細胞 |
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| Research Abstract |
The physiological role of FOXL2 in human granulosa and luteal cellsFOXL2, a forkhead transcription factor gene, have recently been demonstrated to be causative to granulosa cell tumor or primary ovarian failure. FOXL2 is expressed mostly in periocular and ovarian granulosa cells but its function and role remain unknown. Herein we investigated the physiological role of FOXL2 in folliculogenesis and steroidogenesis by ovarian granulosa cells. We clarified the target genes of FOXL2 that are related to sex steroidogenesis and folliculogenesis and FOXL2 is shown to play as a transcription factor in target gene promoters. Thus, FOXL2 is shown to be crucial in the regulationof ovarian function.
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