| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Cell lines derived from human placenta and amnion have been established. And also it has been shown that these cells differentiate into cardiomyocytes and vascular cells. In this study, using the above cell, the possibility of new treatments for various types of heart disease such as heart failure and myocardial infarction were examined. Several iPS cell lines derived from human placenta and amniotic-derived cells were established. Factor responsible for homeostasis of cardiovascular not only endothelial cell-specific molecule was listed up as genes that characterize placental vascular endothelial cells. Cells that can differentiate into cardiomyocytes were localized in the part of tissue derived from fetus of mouse placenta. Myocardial progenitor cell-specific gene-positive cells were observed in the labyrinth layer and chorion frondosum of mouse placenta. These results are novel findings indicate that cells with myocardial differentiation ability were localized in placenta.
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