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Elucidation of the variance of intercellular phosphorylation signaling in hair cells during inner ear disorder

Research Project

Project/Area Number 23791873
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionGunma University

Principal Investigator

MURATA Takaaki  群馬大学, 医学部, 助教 (10569875)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords神経科学 / 内耳障害 / チロシンリン酸化 / シグナル伝達 / 細胞 / 耳科学
Research Abstract

To evaluate phosphorylation state of proteins present in the inner ear organ, we used inner ear organ homogenate from wild mice. Immunoblot analysis indicated that several proteins including cochlin undergo tyrosine phosphorylation with pervanadate stimulation. We investigated the phosphorylation state about full length form of cochlin in pervanadate stimulation with immnunoprecipitation method, and the immnunoprecipitated cochlin protein was indeed tyrosine phosphorylated.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] A new and less invasive procedure for arytenoid adduction surgery: Endoscopic-assisted Arytenoid Adduction Surgery2011

    • Author(s)
      Takaaki Murata, Yoshihito Yasuoka, Tetsuaki Shimada, Masato Shino, Hideki Iida, Katsumasa Takahashi, Nobuhiko Furuya
    • Journal Title

      The laryngoscope

      Volume: 121 Issue: 6 Pages: 1274-1280

    • DOI

      10.1002/lary.21762

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker-induced angioedema in the oral flour and epiglottis2011

    • Author(s)
      Masato Shino, Katsumasa Takahashi, Takaaki Murata, Hideki Iida, Yoshihito Yasuoka, Nobuhiko Furuya
    • Journal Title

      American Journal of Otolaryngology

      Volume: 32 Issue: 6 Pages: 624-626

    • DOI

      10.1016/j.amjoto.2010.11.014

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical evaluation of safety and efficacy of endoscopic-assisted arytenoid adduction surgery2012

    • Author(s)
      Takaaki Murata
    • Organizer
      Combined Otolaryngology Spring Meetings 2012
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 活動性中耳炎を伴う両側聾症例への段階的人工内耳埋め込み術2012

    • Author(s)
      村田 考啓
    • Organizer
      日本耳科学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 嚥下性肺炎と喉頭軟弱症を合併した喉頭裂の1症例2012

    • Author(s)
      村田 考啓
    • Organizer
      日本喉頭科学会
    • Place of Presentation
      金沢市文化ホール(石川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 当科における難聴を合併した広汎性発達障害症例の検討2011

    • Author(s)
      村田考啓
    • Organizer
      第21回日本耳科学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2011-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 当科における難聴を合併した広汎性発達障害症例の検討2011

    • Author(s)
      村田 考啓
    • Organizer
      日本耳科学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 内視鏡下披裂軟骨内転術の術式と治療成績2011

    • Author(s)
      村田 考啓
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] 広汎性発達障害症例における聴性定常反応の特性2011

    • Author(s)
      村田 考啓
    • Organizer
      日本聴覚医学会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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